UNLABELLED The polymerase basic 2 (PB2) subunit of the RNA polymerase complex of seasonal human influenza A viruses has been shown to localize to the mitochondria. Various roles, including the regulation of apoptosis and innate immune responses to viral infection, have been proposed for mitochondrial PB2. In particular, PB2 has been shown to inhibit interferon expression by associating with the...

Post-translational modifications of viral proteins play important roles in regulating viral replication. Here we demonstrated that the PB2 of influenza A virus (IAV) can be modified by NEDD8. We revealed that E3 ligase HDM2 can promote PB2 NEDDylation. Overexpression of either NEDD8 or HDM2 can inhibit IAV replication, while knockdown of HDM2 has the opposite effect. Then we identified residue ...

Microstructure Design In article number 2203229, Shikuan Yang and co-workers propose an avenue to regulate the morphologies of electrodeposits during anodic electrodeposition process by introducing intermediate valence ions (e.g., Pb2+, Mn2+, etc.) into electrolyte solutions. The could react with electrochemically oxidized Ag2+/Ag3+ strong oxidation abilities, affecting growth kinetics Ag7O8NO3...

The suspended particulate material (SPM) present in waters has fundamental importance for a better understanding of environmental behaviors aquatic pollutants. This work determined the physicochemical parameters (pH, temperature, conductivity, total organic carbon and metals concentration) water samples from Mundau-Manguaba estuarine-lagoon system, Alagoas, Brazil. extracted characterized matte...

Herein, a sensor platform, Bi/carboxyphenyl-modified glassy carbon electrode (Bi/CP/GCE), is presented for the detection of Cd2+ and Pb2+ using square wave anodic stripping voltammetry (SWASV). The was obtained through electrografting GCE 4-carboxybenzene diazonium tetrafluoroborate (4-CBD) in situ electrodeposition Bi3+. stability grafted layer proposed mechanism interaction between metal ions...

Lead, a toxic heavy metal, is considered one of the most serious pollutants in water environment, posing grave threat to human health and global ecosystem. In this work, simple, fast sensitive sensor strategy for detecting trace lead ions (Pb2+) was proposed. The disposable electrochemical fabricated with screen-printed carbon electrode (SPCE), working modified single step situ polymerized phyt...

In this study, a performance evaluation of an aluminium oxide modified onion skin waste (Al2O3/OSW) for the removal heavy metal ions (Pb2+ and Cd2+) from aqueous solution was investigated under batch mode adsorption. The surface morphology, elemental composition, functional groups, textural characteristics charge as-made Al2O3/OSW adsorbent were examined using SEM, EDX, FTIR, BET area pHpzc tec...

The use of dead, dried aquatic plants, for water removal of metals derived from industrial activities as a simple biosorbent material has been increasing in the last years. The mechanism of simultaneous metal removal (Cd2+, Ni2+, Cu2+, Zn2+ and Pb2+) by 3 macrophytes biomass (Spirodela intermedia, Lemna minor and Pistia stratiotes) was investigated. L. minor biomass presented the highest mean r...

co-precipitation procedure was applied in order to obtain different kinds of magnetic nanoadsobents for the removal of pb(ii) and cu(ii) toxic metal ions from wastewater samples. prepared nanoadsorbents were characterized by fourier transform infrared spectroscopy (ft-ir), x-ray diffractometer (xrd), scanning electron microscopy (sem) and thermogravimetric analysis (tga). the average sizes of t...