OBJECTIVES The present study evaluates the long-term course of aortic valve disease and the need for aortic valve surgery in patients with rheumatic mitral valve disease who underwent mitral valve surgery. BACKGROUND Little is known about the natural history of aortic valve disease in patients undergoing mitral valve surgery for rheumatic mitral valve disease. In addition there is no firm pol...

INTRODUCTION valve disease is an important cause of heart failure. There is a direct relationship between valve deterioration and the patient's inflammatory status and cytokines: interleukin-6, interleukin-1, tumor necrosis factor, and C-reactive protein, involved in this major state of inflammation. OBJECTIVE to report a series of cases of valve replacement, using a bioprosthetic or mechanic...

BACKGROUND Prosthetic valve leak is a possible complication of surgical valve replacement. Although uncommon, its consequences may be serious. Few studies correlate the degree of prosthetic valve leak with clinical events. OBJECTIVE To compare the postoperative outcome of patients with mild/moderate (Mi/Mo) or severe (Sev) prosthetic valve leak METHODS A total of 185 patients with prostheti...

The calculation and comparison of relative survival rates after interventional studies is a method that permits correction for important demographic variables, thereby adjusting for the "background mortality" in the general population. Long-term relative survival rates were analyzed in a consecutive series of 2,805 Swedish patients who, on the basis of clinical symptoms, underwent aortic valve ...

OBJECTIVES Whether to repair or replace the mitral valve for patients with significant mitral regurgitation undergoing aortic valve replacement is still controversial. METHODS From January 1990 to December 2011, a total of 663 patients underwent aortic valve replacement combined with mitral valve surgery. Among these, 253 patients (mean age 55.9 ± 14.5 years, 91 females) with moderate-to-seve...

This study aimed to report on the prospective outcomes in areas of depression, quality life (QL), angina, and frailty surgical aortic valve replacement (SAVR) transcatheter (TAVR) patients with stenosis undergoing intervention.

Heart valve replacement is fast becoming a routine surgery worldwide and heart valve prostheses are today considered among the most widely used cardiovascular devices. Mechanical and bioprostheses have been the traditional choices to the replacement surgeries. However, such valves continue to exposed patients to risks, including thrombosis, infection and limited valve durability. In recent year...

The requirement of varying doses of warfarin for different individuals can be explained by environmental and genetic factors. We evaluated the frequency of vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) variants together with patientdemographic characteristics and investigated their association with warfarin dose requirement with the ob...

BACKGROUND This is a validation study comparing the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II with the previous additive (AES) and logistic EuroSCORE (LES) and the Society of Thoracic Surgeons' (STS) risk prediction algorithm, for patients undergoing valve replacement with or without bypass in Pakistan. PATIENTS AND METHODS Clinical data of 576 patients undergoing v...