INTRODUCTION Achondroplasia is a genetic disorder of bone growth. Congenital spinal stenosis is a well-known complication of this disease, but, to the best of our knowledge, no cases involving combined stenosis with congenital lumbar spinal stenosis and ossification of the ligamentum flavum in achondroplasia have been reported previously. In this report, we describe a case of a patient with con...

The sclera is the tough outer covering of the eye that provides structural support and helps maintain intraocular pressure. In some fishes, reptiles, and birds, the sclera is reinforced with an additional ring of hyaline cartilage or bone that forms from scleral ossicles. Currently, the evolutionary and genetic basis of scleral ossification is poorly understood, especially in teleost fishes. We...

VEGF is a well known angiogenic peptide which has been shown to be central to endochondral ossification. Secondary fracture healing involves a combination of intramembranous and endochondral ossification. VEGF has been recently shown to be chemotactic for osteoblasts [1] and chondroclasts and central to endochondral ossification [2]. Fracture healing physiology involves a complex cascade of num...

Ossification of the stylohyoid ligament is very common in the Caucasian population. More than 9000 descriptions of apparently isolated case reports on PubMed have been cited over the last 20 years, often associated with an incidental finding on imaging after neck trauma. No cases of familial ossification have been described. We document a family with several affected members, each with an ossif...

Background: Pilomatricoma, the most common hair follicle tumor, has a wide variety of clinicopathological characteristics and is often misdiagnosed. Objective: The aim of this study was to explain the clinical and histological spectrum of tumor in order to help for its better diagnosis. Patients and Methods: In a retrospective descriptive study, the clinical and histological features of pilomat...

Ossification of the tentorium cerebelli over the trigeminal notch is rare, but it may cause compression of the trigeminal nerve, leading to trigeminal neuralgia (TN). We were unable to find any previously reported cases with radiological evaluation, although we did find one case with surgically proven ossification of the tentorium cerebelli. Here, we present a case of TN caused by tentorial oss...

Albright"s hereditary osteodystrophy (AHO) is a complex genetic disorder characterized by brachydactyly, gonadotropin resistance, hypothyroidism, pseudohypoparathyroid syndrome and heterotopic ossification. Heterotopic ossification rarely occurs in the maxillofacial region. In this article, we present such a case, describe the etiology, characteristics and treatment of AHO and suggest a potenti...

background: this study addresses the null hypothesis that there is no expansion of heterotopic ossification (ho) in the elbow beyond what can be seen early on.   methods: the area of ho was measured on lateral radiographs of 38 consecutive patients that had operative treatment of ho between 2000 and 2013. measurements from radiographs obtained between 3 to 7 weeks were compared to measurements ...

background: oxaliplatin (ox) significantly enhanced the antitumor activity of 5-fu in patients with advanced colorectal cancer and recently some phase ii trials have evaluated the feasibility and efficacy of oxaliplatin in neoadjuvant setting for treatment of locally advanced rectal cancer. on the other hand various studies have demonstrated that the overexpression of thymidylate synthase (ts) ...

INTRODUCTION Heterotopic ossification is a rare complication of musculoskeletal injuries, characterized by bone growth in soft tissues. Percutaneous antegrade intramedullary nailing represents the 'gold standard' for the treatment of femur shaft fractures. Minor bone growth is frequently seen around the proximal end of reamed femoral nails (so-called 'callus caps'), which are asymptomatic and l...