A paper describes the main events and periods in the history of Pathophysiology as a curriculum element and research area. The national schools of Pathophysiology in Russia, continental Europe, Asia and British-North American world are compared, their history discussed. The evolution of Pathophysiology towards Systemic Pathobiology, its crisis and perspectives are evaluated. The priority of Rus...

Artem Shkumatov, Michael Thompson, Kyoung M. Choi, Delphine Sicard, Kwanghyun Baek, Dong Hyun Kim, Daniel J. Tschumperlin, Y. S. Prakash, and Hyunjoon Kong Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota; Department of Physiology and Biomedical Engineering, M...

Waldemar Debinski, MD, PhD Director of Brain Tumor Center of Excellence, Comprehensive Cancer Center of Wake Forest University, Departments of Neurosurgery, Radiation Oncology, & Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA Tel.: +1 336 716 9712 Fax: +1 336 713 7639 [email protected] “Just about everything that relates to gl...

Ignatius W. Fong, Thomas Quinn, Erwin Blessing, Cho-chou Kuo, Raffaele Malinverni, Michael Lauer, Steven Mawhorter, Kurt Bachmaier, Michael Rosenfeld, Christopher Taylor, and Guangming Zhong Department of Medicine, University of Toronto, St. Michael’s Hospital, and Amgen Institute, Toronto, and Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada; Division of Infectious ...

Angioimmunoblastic T-cell lymphoma (AITL) is a frequent subtype of peripheral T-cell lymphoma (PTCL) that is clinically characterized by generalized lymphadenopathy, extranodal involvement, advanced stage at presentation, hypergammaglobulinemia, and significant immune dysregulation resulting in infections as the most common cause of death. Recent advances in pathobiology of AITL have improved o...

1 Department of Biomedicine, School of Health Science, Dilla University, Dilla, Ethiopia 2 Department of Medical Microbiology, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia. 3 Department of Tropical and Infectious Diseases, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia. 4 Department of Microbiology, School of Biomed...

Nitric oxide (NO) is a diffusible gas with diverse roles in human physiology and disease. Significant progress in the understanding of its biological effects has taken place in recent years. This has led to a better understanding of the pathobiology of pulmonary hypertension (PH) and the development of new therapies. This article provides an overview of the NO physiology and its role in the pat...

Ludek Zurek and Anuradha Ghosh 10 Department of Diagnostic Medicine and Pathobiology; College of Veterinary Medicine 11 Department of Entomology; College of Agriculture 12 Kansas State University, Manhattan, KS 66506 13 14 15 16 17 18 *Corresponding author 19 Department of Entomology 20 Department of Diagnostic Medicine and Pathobiology 21 Waters Hall 034 22 Kansas State University 23 Manhattan...

Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertension (PH). Candidate genes, important to the pathobiology of the disease, have been investigated. Rodent models enable the manipulation of selected genes, either by transgenesis or targeted...

Neuroblastoma is a pediatric malignant tumor of the postganglionic sympathetic nervous system that usually develops in the adrenal gland or in nonadrenal abdominal or thoracic sites.[1] It is the most common malignancy in infants and the most common extracranial solid tumor of childhood, with approximately 650 cases diagnosed annually in the United States.[2] The dramatic age-related survival d...