A technique is described for collecting thoracic duct lymph in a portable glass saddle from an unrestrained rat. Uniformly labelled oleic acid in various physical states was given to rats with thoracic duct and bile fistulae to study the influence of bile salts on the amount absorbed and on the route of transport and esterification after absorption. It is suggested that in addition to their emu...

IMPORTANCE Approximately 5% to 10% of patients continue to experience persistent epiphora following an anatomically successful dacryocystorhinostomy (DCR) for nasolacrimal duct obstruction or stenosis. OBJECTIVE To investigate the management and success rate of so-called "functional failure" of DCR for nasolacrimal duct obstruction by experienced lacrimal surgeons. DESIGN, SETTING, AND PART...

Abstract Summary: Primary sclerosing cholangitis and colitis are known predisposing factors for bile duct cancer, but their exact pro-oncogenic mechanisms unclear. In this issue of Cancer Discovery, Zhang colleagues identify intestinal barrier impairment as a key mechanism, resulting in gut microbes spilling into the portal vein, turn recruiting immunosuppressive myeloid-derived suppressor cell...

Patent ductus arteriosus (PDA) is an extracardiac left to right shunt. It should be corrected at an early age, but some patients may survive into adult life even without repair. Anesthetic management for adult patients with PDA poses many challenges for the anesthesiologist due to alterations in the cardiopulmonary physiology. We report successful anesthesia management of a case of an adult pat...

Background Patients with congenital obstructive left heart lesions often depend on ductal blood flow to supplement their systemic circulation. Echocardiography (ECHO) is routinely used to assess duct patency and shunt direction, but may be of limited value in shunt quantification. We hypothesized that ECHO assessment of net direction and magnitude of blood flow across a patent ductus arteriosus...

Congenital hernia of umbilical cord is a less frequent entity in newborns and occasionally associated with other maladies. Herein, we report three unusual cases of hernia of umbilical cord. First case was associated with in-utero evisceration of entire small bowel through the presumably ruptured hernia of umbilical cord and other two cases had associated patent vitellointestinal duct (PVID). Al...

Peroxisome proliferator-activated receptor (PPARγ) has been shown to have a protective role in the nephron through its ability to inhibit a transforming growth factor- (TGF-β) mediated fibrotic response. In contrast, PPARγ was also shown to induce a mesenchymal transformation in epithelial intestinal cells. A fibrotic response in the collecting duct has only recently been established; however, ...