Background: Experimental evidence supports a preventative role for non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson’s disease (PD). Methods: We investigated associations between use of aspirin, nonaspirin NSAIDs, and acetaminophen and PD in a large population-based casecontrol study using Danish health and pharmacy registries. We identified 1,931 PD cases reported in hospital or outp...

Introduction The human nucleus accumbens (NA), a limbic-motor interface, plays an important role in motivation and emotional processes and is involved in some of the most disabling neuropsychiatric disorders such as Parkinson’s disease (PD). PD, a common disorder of dopamine (DA) dysfunction, is characterised by motor, psychiatric and autonomic symptoms. Mavridis’ atrophy (MA) is called the par...

BACKGROUND The mechanism underlying non-motor symptoms in Parkinson's disease has not yet been elucidated. In this study, we hypothesized that Parkinson patients with more non-motor symptoms have a different pattern of striatal dopamine depletion, particularly in areas other than the sensorimotor striatum, compared to those with fewer non-motor symptoms. METHODS We conducted a prospective sur...

Amyloid protein aggregation is a key factor in the development of variety serious diseases humans, commonly named as amyloidoses (Alzheimers and Parkinsons diseases, type II diabetes, etc.), determinant protein-based inheritance lower eukaryotes. In yeast, translation termination Sup35 one most extensively studied amyloidogenic proteins. Aggregation (induction [PSI+] prion) decreases its functi...

Synchronization processes are of crucial importance for brain function. Well-coordinated synchrony within and between neuronal populations appears to be an important mechanisms for neuronal signaling and information processing. In contrast, pathologically strong synchronization may severely impair brain function. For instance, resting tremor in Parkinson’s disease is caused by a synchronized po...

BACKGROUND While the cause of Parkinson's disease (PD) remains unknown, evidence suggests certain environmental factors, such as well water drinking, herbicides, pesticides exposure and neurotoxins, may trigger the chain of oxidative reactions culminating in the death of dopaminergic neurons in substantia nigra to cause Parkinsonism. To investigate the possible impact of environmental risk fact...

OBJECTIVE Reduced verbal fluency (VF) has been reported in patients with Parkinson's disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. METHOD Eleven PD patients performed VF tasks in their STN DBS ON and OFF conditio...

In recent years, applications of data mining methods are become more popular in many fields of medical diagnosis and evaluations. The data mining methods are appropriate tools for discovering and extracting of available knowledge in medical databases. In this study, we divided 11 data mining algorithms into five groups which are applied to a dataset of patient’s clinical variables data with Par...