Primary hyperparathyroidism (P-HPT) is now recognized as one of the most common of all endocrine disorders. When defined by clinical and pathological parameters, solitary adenomas account for 80-85% of cases of P-HPT, hyperplasias for 10-15% and carcinomas for less than 1% in the US and most Western European countries. However, the incidence of parathyroid carcinoma has been reported to be as h...

UNLABELLED We present the case of a patient with metastatic parathyroid carcinoma whose hypercalcaemia was medically managed through two pregnancies. The diagnosis was made when the patient presented with chronic knee pain and radiological findings consistent with a brown tumour, at the age of 30. Her corrected calcium and parathyroid hormone (PTH) levels were significantly elevated. Following ...

Parathyroid carcinoma (PCA), accounting for less than one per cent of all endocrine malignancies, is a rare cause of primary hyperparathyroidism. A diagnosis of parathyroid carcinoma may be challenging in the presence of localised disease and involves a histological diagnosis based on capsular, vascular, or perineural invasion or the presence of metastasis. Distant metastasis remains a rare pre...