Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/- mice with a diet low in calcium and vitamin D so as to expose any defects in parathyroid function. This led to a higher mortality among Gata3+...

Primary hyperparathyroidism due to ectopic parathyroid adenoma is not infrequent. Primary hyperparathyroidism caused by unusual thymic nonadenomatous nonencapsulated parathyroid tissue has been reported before. Both can cause unsuccessful neck explorations. Here we presented for the first time a patient with hyperparathyroidism due to ectopic parathyroid adenoma concomitant to the presence of t...

Parathyroid crisis, also known as a parathyroid storm, is a rare and serious complication of primary hyperparathyroidism. Four cases are reported here in which patients presented to hospital with general complaints due to hypercalcemia secondary to hyperparathyroidism. Blood test results upon admission showed high levels of serum calcium and parathyroid hormone, and medical treatment initiated ...

Intrathyroidal parathyroid carcinoma is an exceedingly rare cause of primary hyperparathyroidism. A 51-year-old African American female presented with goiter, hyperparathyroidism, and symptomatic hypercalcemia. Sestamibi scan revealed diffuse activity within an enlarged thyroid gland with uptake in the right thyroid lobe suggestive of hyperfunctioning parathyroid tissue. The patient underwent t...

because of superficial location and not being covered by boney structure, thyroid is the ideal organ for 2-dimensional gray scale ultrasonography. availability of relatively low cost equipment and ever increasing number of endocrinologists with expertise in thyroid ultrasound has made it an integral part of thyroid practice in the office of endocrinologists. in particular, the current recommend...

in mammals, phosphocalcic and bone metabolisms are mainly regulated by parathyroid hormone, parathyroid hormone-related peptide (pthrp) and 1α,25-dihydroxyvitamin d or calcitriol. in camels, circulating levels of calcitriol are 10 times higher than those determined in other ruminants and further increase during early lactation. calcitriol and parathyroid-related peptide stimulate intestinal abs...

Primary hyperparathyroidism is most commonly caused by either a parathyroid adenoma or parathyroid hyperplasia. Parathyroid adenomas also rarely attain huge proportions. We present a case of a 63-year-old female patient causing hypercalcemia and the mass which is located in the mediastinum. High intact parathormone level secondary to an ectopic hypersecretory parathyroid adenoma were detected (...

A synthetic analog of bovine parathyroid hormone (bPTH), [tyrosine-34] bPTH-(7-34)NH2, was found to inhibit parathyroid hormone action in vivo. When the analog and parathyroid hormone were infused simultaneously to rats at a molar ratio of 200 to 1, the analog inhibited the excretion of urinary phosphate and adenosine 3',5'-monophosphate. When infused alone at the same dose rate, the analog was...

We describe a 59-year-old woman who presented with pathological osteoporosis, cerebral infarction, hypercalcemia, and markedly high parathyroid hormone levels. The diagnosis was primary hyperparathyroidism, and parathyroidectomy was performed. Histopathological examination showed parathyroid adenoma. Surgical exploration for recurrent parathyroid carcinoma was undertaken at 2 and 3 years after ...

The research included Estimation of some biochemical parameters like Hepcidin hormone , parathyroid hormone, vitamin D3 ,iron ,calcium, total cholesterol, triglycerides, HDL, VLDL, paraoxonase, glutathione-s-transferase, BMI ,and ceruloplasmin in serum women with osteoporosis after menopausal, the results shewed a decrease levels (Hepcidin D, calcium, hemoglobin, BMI, and albumin) blood patient...