OBJECTIVE To find out whether changes in the daily prothrombin time are of prognostic importance in patients with paracetamol induced fulminant hepatic failure. DESIGN Retrospective study. SETTING The Liver Unit, King's College Hospital, London. PATIENTS 150 Consecutive patients with paracetamol induced fulminant hepatic failure admitted between October 1986 and February 1989. MAIN OUTC...

Paracetamol (acetaminophen) poisoning is common throughout the world. The management of nonstaggered (acute) paracetamol overdose is based on the plasma paracetamol concentration plotted on a treatment nomogram. In the UK there are two treatment lines on this nomogram, with the lower treatment line used for individuals felt to be at 'high risk' of paracetamol-related hepatotoxicity either as a ...

The numbers of deaths from paracetamol poisoning have risen steadily in England and Wales since the first cases of fulminant hepatic failure caused by paracetamol poisoning were reported in 1966.'-3 In 1984 there were 176 deaths from paracetamol alone and a further 305 from paracetamol with other drugs, notably dextropropoxyphene.4 Adults account for most of the serious and fatal cases; young c...

The aim of study is to reduce hepatic damage from paracetamol will be funded using alcohol extract for ginger and vitamin E as antioxidants in male New Zealand rabbits. Paracetamol (acetaminophen) a widely used over-the-counter analgesic antipyretic drug which known cause liver injuries both humans experimental animals when administered overdose. current was conducted at the animal house Colleg...

Introduction: The paracetamol is the most widely used painkiller to dental pain. Patients self-medicating with for pain had 12.8 more times lead overdose than patients other pains. aim of this work was propose a standardized management in case from clinical report. Observation: A 56-year-old man referred General Emergency Department because he ingested 32 grams less 24 hours due He state haemod...

Acetaminophen (paracetamol) toxicity is an important cause of morbidity and mortality worldwide. It estimated that poisoning contributes to more than 1 million poisonings up half a deaths each year, yet it preventable treatable. the second most common liver transplantation However, studies concerning in Botswana are scant, although has been reported 6.7% total injuries ranked third next falls a...

Treatment of the coagulation disturbances developing with hepatic damage following a paracetamol overdose was assessed in a controlled trial of 22 patients, one half being given heparin and fresh frozen plasma and the other fresh frozen plasma alone. No significant difference was observed either in the speed of correction of the coagulation defect or in the clinical outcome. Two-thirds of the p...

Hepatic diseases are serious health issues as various pharmaceuticals, xenobiotics, environmental/chemical pollutants, some natural products and dietary supplements when used in overdose have tendency to cause hepatotoxicity. Present study was aimed at investigating hepatoprotective activity of aqueous methanolic extract of Euphorbia prostrata against paracetamol and carbon tetrachloride induce...

Liver toxic is an acute effect of paracetamol (500 mg/kg) Consequently, we investigated how toxicity affected liver cell enzymes in this study aspartate aminotransferase (GOT) and alanin catalyzes (GPT), Glutation (GSH( total protein ,glucose , body weight male rats that drenched Anethum graveolens (Dill) . were used research 40 adult rats, 172-311 gm, age 8-12 weeks, isolated a environment at ...

Aims/Objectives/Background Paracetamol overdose is the most common drug in UK. The standard treatment of toxicity intravenous N-acetylcysteine (NAC) which usually given as a 21-hour infusion UK hospitals. A 12-hour known ‘SNAP’ regimen has been implemented some centres and appears on TOXBASE. SNAP associated with fewer anaphylactoid reactions than treatment. was initiated two District General H...