نتایج جستجو برای: par levels
تعداد نتایج: 963352 فیلتر نتایج به سال:
Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein, which is involved in physiological and malignant invasion processes. It is activated by serine proteases such as thrombin through a unique form or by specific synthetic peptides. In this study, we determined the expression of PAR-1 in five nasopharyngeal carcinoma (NPC) cell lines with different characteristics of invasivene...
Tryptase exacerbates intestinal ischemia-reperfusion injury, however, the direct role of tryptase in intestinal mucosal injury and the underlying mechanism remains largely unknown. Protease-activated receptor 2 (PAR‑2), commonly activated by tryptase, interacts with various adaptor proteins, including β‑arrestin‑2. The present study aimed to determine whether tryptase is capable of inducing int...
l’histoire se passe en 1826, dans la france de la restauration. julien sorel, un jeune homme de dix-neuf ans issu du peuple n’est pas taillé pour les travaux manuels comme le voudrait son père, un fervent "scieur". au contraire, julien est un intellectuel ambitieux et cherche à s’instruire pour échapper à sa classe sociale. il se révèle très doué et c’est pour cela qu’il finit par entrer comme ...
Le malade contaminé par le Sida subit une double souffrance: souffrance physique tout d’abord, du fait des douleurs provoquées par sa maladie, douleur morale et sociale enfin, en raison des attitudes de rejet dont il est l'objet de la part des personnes effrayées par le virus. Le Sida demeure encore un sujet tabou dans plusieurs pays. Ce qui se traduit souvent par un ...
Lorsqu’on s’interroge sur sa propre identité de l'Etat face au problème du sida, il faut certes y réfléchir un moment, tant les références personnelles en la matière peuvent être diverses. Nous avons toutes et tous une idée, une image, une réaction face au mot sida, ce que cela représente pour nous, nos proc...
We examined the hypothesis that oxidants generated nitroso derivatives, activated latent matrix metalloproteinase (MMP), and induced proteinase-activated receptor 1 (PAR-1), leading to disconnection between the endothelium and myocytes. Administration of cardiospecific tissue inhibitor of metalloproteinase-4 (TIMP-4/CIMP) ameliorated the oxidative-proteolytic stress and endothelial-myocyte unco...
In chronic lymphocytic leukemia (CLL), mutation and loss of p53 and ATM abrogate DNA damage signalling and predict poorer response and shorter survival. We hypothesised that poly (ADP-ribose) polymerase (PARP) activity, which is crucial for repair of DNA breaks induced by oxidative stress or chemotherapy, may be an additional predictive biomarker and a target for therapy with PARP inhibitors.We...
BACKGROUND Allergic asthma is on the rise in developed countries. A common characteristic of allergens is that they contain intrinsic protease activity, and many have been shown to activate protease-activated receptor (PAR)-2 in vitro. The role for PAR-2 in mediating allergic airway inflammation has not been assessed using a real world allergen. METHODS Mice (wild type or PAR-2-deficient) wer...
BACKGROUND Galectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3 silencing, we demonstrated here that galectin-3 plays a key role in up-regulating the expressions of protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1) PAR-1 thereby promoting gastric cancer metastasis...
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