Cervical cancer is the second most common malignancy and a leading killer among women worldwide. Seventy percent of these cervical cancers are known to be caused by Human Papilloma Virus, which is transmitted primarily by sexual contact. The use of Human Papilloma Virus prophylactic vaccine among young adolescents, who have not been previously exposed to the infection, as primary prevention hol...

To identify the genetic events which may play a role in the development of cervical carcinoma, we performed a detailed allelotype analysis utilizing DNA from 53 primary tumors and corresponding normal cells and 57 polymorphic probes mapped to each of the chromosomal arms, excluding the short arms of the acrocentric chromosomes. Loss of heterozygosity (LOH) of >25% was observed at sites on 11 ch...

To determine the relationship between cellular uptake of cadmium and content of metallothionein, we measured uptake of 109Cd in cells that differed in content of metallothionein (MT). MT cells were derived from NIH/3T3 cells by transfection with a plasmid containing the genome of bovine papilloma virus and the mouse metallothionein-I gene, driven by the promotor for the glucose-regulated protei...

Buschke-Löwenstein tumor is a rare manifestation of a sexually transmitted human papilloma virus infection that affects the anogenital area. Wide local excision of the lesion is the mainstay of treatment. Malignancy though must be excluded.

BACKGROUND Receiving a healthcare provider's recommendation is a strong predictor of HPV vaccination, but little is known empirically about which types of recommendation are most influential. Thus, we sought to investigate the relationship between recommendation quality and HPV vaccination among U.S. adolescents. METHODS In 2014, we conducted a national, online survey of 1495 parents of 11-17...

These studies make plain that the Shope papilloma virus induces the production of an arginase in rabbit squamous epithelium, and provide evidence that the information for the synthesis of the enzyme is derived from the virus rather than the rabbit. This form of induction is therefore different from that brought about by chemicals such as galactosides (36). Striking differences were shown betwee...

Laryngeal papillomas are caused by infection of the laryngeal epithelium by human papillomavirus type 6 or type 11 (HPV-6/-11). Previous studies in our laboratory have demonstrated an increase in PI3 kinase levels in papilloma tissue. However, activation of the downstream effector of PI3 kinase, protein kinase B (PKB/Akt), was reduced. This observation was explained by the elevated expression o...

Background: Schneiderian papillomas are uncommon benign tumors of the sinonasal area. They tend to present local aggressiveness and recurrence, and some undergo malignant progression. This study aimed to search of humanpapillomavirus (HPV) and Epstein–Barr virus (EBV) in sinonasal inverted papilloma (IP) in order to elucidate possible role in its pathogenesis. Methods: Forty-eight IPs were subj...

Objective: Cervical cancer is caused by human papilloma virus (HPV) infection, and cervical intraepithelial neoplasia (CIN) a precancerous lesion. Common treatments for CIN are conization laser vaporization. HPV testing useful predicting residual or recurrent disease after surgical treatment. We performed high-risk (HR-HPV) genotyping postoperatively to examine the positivity rate determine whe...