Anti-infective drug development depends to a great extent on enrolling the “correct” subjects in Ph II–III clinical trials – i.e., those who can show a therapeutic benefit from the anti-infective therapy. For example, while at Lederle Labs, I worked on a new indication for MINOCIN®-namely, treatment of moderate-to-severe periodontitis. MINOCIN®-reduces the numbers of the putative periodontal pa...

The recent advent of high-throughput approaches has revealed widespread transcription of the human genome, leading to a new appreciation of transcription regulation, especially from noncoding regions. Distinct from most coding and small noncoding RNAs, long noncoding RNAs (lncRNAs) are generally expressed at low levels, are less conserved and lack protein-coding capacity. These intrinsic featur...

Most common techniques for spatialization require the listener to be positioned at a “sweet spot” surrounded by loudspeakers. For practical concert, stage, and installation applications such layouts may not be desirable. Distance-based amplitude panning (DBAP) offers an alternative panningbased spatialization method where no assumptions are made concerning the layout of the speaker array nor th...

The city of Bou Sa?da is one the Algerian cities that have diverse tourism resources, but it has not been adopted as a premier tourist spot nor benefited from programs established within national strategy for sustainable development Horizons 2030, which made weak compared to other regions similar elements. This study aims evaluate existing address shortcomings and provide solutions by focusing ...

Modern marine propulsion systems must be reliable, energy efficient, environmentally friendly, and economical. Efforts to reduce fuel costs carbon dioxide (CO2) emissions per nautical mile have a significant impact on the choice of system. Considering that there is no alternative for maritime transport, various technical technological solutions are being considered aim improve efficiency negati...

Band steaming is a non-chemical weed control method of increasing interest for highly remunerative, low competitive crops. This study aimed to test the field application new prototype band-steaming machine in three organic fields under contrasting Mediterranean environmental conditions. Trials were conducted carrot real-field conditions investigate effects doses and one (no steaming) on vegetat...

The apparent position of speech and music sound sources was investigated using both a two channel loudspeaker array and a three channel loudspeaker array. The results showed that a sine-cosine pan law was reasonably accurate for the three channel array, but consistently produced sharp images who’s positions were consistently wider than expected with a two channel array. The discrepancy was inve...