The pancreas is a highly important organ, since it produces insulin and prevents the occurrence of diabetes. Although rare, pancreatic cancer lethal, with small life expectancy after being diagnosed. one organs less studied in field biophotonics. With objective acquiring information that can be used development future applications to diagnose treat diseases, spectral optical properties rabbit w...

Introduction/Objective. Pancreatic cancer may be accompanied by infections caused various microorganisms. It is uncertain wheatear pancreatic infection precedes the development of or vice versa. The aim this study to analyze routes from duodenum through duct determine what types microorganisms can get into pancreas and nearby tissue. Methods. In patients subjected cephalic duodenopancreatectomy...

Objective: To determine whether bacteria are present in the pancreas of pancreatic cancer and non-cancer subjects and examine whether bacterial profiles vary by site and disease phenotype. Design: 77 patients requiring surgery for pancreatic diseases, or diseases of the foregut, at the Rhode Island Hospital (RIH) were recruited into this study between 2014 and 2016. In addition, 36 whole pancre...

Objective: To determine whether bacteria are present in the pancreas of pancreatic cancer and non-cancer subjects and examine whether bacterial profiles vary by site and disease phenotype. Design: 77 patients requiring surgery for pancreatic diseases, or diseases of the foregut, at the Rhode Island Hospital (RIH) were recruited into this study between 2014 and 2016. In addition, 36 whole pancre...

Purpose:Discriminant markers for pancreatic cancer detection are needed. We sought to identify and validate methylated DNA markers for pancreatic cancer using next-generation sequencing unbiased by known targets. Experimental Design: At a referral center, we conducted four sequential case–control studies: discovery, technical validation, biologic validation, and clinical piloting. Candidatemark...

The American Cancer Society reported the trends in five-year survival for pancreas cancer (predominately pancreatic ductal adenocarcinoma) in 2010. For the cohorts of patients 1975-1977, 19841986, and 1999-2005 the five-year survival rates are a dismal three percent, three percent, and six percent respectively. This is in stark contrast to overall cancer survivals from all sites for the same ti...

After multiple positive studies, gemcitabine, approved for the treatment of pancreas cancer by the FDA in 1977, became standard of care. Whether this therapeutic advance has translated into longer survival for pancreas cancer patients in general has not been established. This study, derived from SEER (Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute) d...

BACKGROUND Pancreatic ductal adenocarcinoma, which represents 90% of pancreatic cancers, is one of the most lethal and aggressive malignancies. Operative resection remains the only treatment providing prolonged survival, however, recurrence of pancreatic ductal adenocarcinoma occurs in up to 80% of patients with pancreatic cancer within 2 years of a potential curative resection. There are few r...

Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored cell surface antigen with an organ-dependent expression pattern in cancers; e.g., up-regulated in prostate cancer and down-regulated in gastric cancer. Previously it was reported that PSCA is not expressed in the normal pancreas but aberrantly expressed in pancreatic cancer. In this present study, we identified PSCA ex...