Pericentrin is a critical centrosomal protein required for organizing pericentriolar material (PCM) in mitosis. Mutations in pericentrin cause the human genetic disorder Majewski/microcephalic osteodysplastic primordial dwarfism type II, making a detailed understanding of its regulation extremely important. Germaine to pericentrin's function in organizing PCM is its ability to localize to the c...

MicroRNA-122 (miR-122) is one of the most abundant miRs in the liver. Previous studies have demonstrated that miR-122 plays a role in inflammation in the liver and functions in hepatic stellate cells (HSCs), which reside in the space of Disse. Here, we showed that the transient inhibition of PKR-activating protein (PACT) expression, by miR-122 or siRNA targeting of PACT, suppressed the producti...

We report our observations on 4 AGNs viz, Mkn421, Mkn501, 1ES1426+428 and ON231 belonging to a sub-class called blazars. The observations were carried out using the Pachmarhi Array of Cherenkov Telescopes and span about 6 years period from 2000 to 2005. We discuss our methods of analysis adopted to extract the gamma ray signal from cosmic ray background. We present our results on the emission o...

McW illiam, P . J., W inton , P. J. and Crais, E . R., 1996, Practical Strategies for Family-Centered Early Intervention (San Diego: Singular Publishing Group). Menn, L ., 1976, Evidence for an interactionist discovery theory of child phonology. Papers and Reports on Language Development, 12, 169–177. Stanford University. M iccio , A . W., 1995, Metaphon: factors contributing to treatment outco...

BACKGROUND The need for deliberately coordinated care is noted by many national-level organizations. The Department of Veterans Affairs (VA) recently transitioned primary care clinics nationwide into Patient Aligned Care Teams (PACTs) to provide more accessible, coordinated, comprehensive, and patient-centered care. To better serve this purpose, PACTs must be able to successfully sequence and r...

BACKGROUND Obesity is highly prevalent among Veterans. In the United States, the Veterans Health Administration (VHA) offers a comprehensive weight management program called MOVE!. Yet, fewer than 10 % of eligible patients ever attend one MOVE! visit. The VHA has a patient-centered medical home (PCMH) model of primary care (PC) called Patient-Aligned Care Teams (PACT) at all Veterans Affairs (V...

International agreements in the practice of diplomatic relations are an important aspect. Where its implementation, role international law is based on fact that mostly consists treaties. One example treaties Pact Bogota. The Bogota United States Agreement Settlement Pacific region signed by independent American republics gathered at Ninth Conference Bogota, Colombia. member countries this pact ...