Regional brain blood flow was determined in 23 awake, unparalyzed gerbils with a simplified indicator-fractionation technique. The use of intravenous 14C-butanol, an indicator that is freely diffusible into the brain, eliminated the need for repetitive sampling of arterial and cerebral venous blood and reduced the period of indicator circulation of 10 seconds. Gerbils spontaneously breathing ro...

BACKGROUND Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis. This study explored feasibility of, effectiveness and safety of low flow extracorporeal CO2 removal (ECCO2R). METHODS This was a prospective pilot study, using the Abylcap® (Bellco) ECCO2R, with crossover off-on-off design (2-h blocks) under ...

BACKGROUND Chronic obstructive pulmonary disease (COPD) patients may develop metabolic alkalosis during weaning from mechanical ventilation. Acetazolamide is one of the treatments used to reverse metabolic alkalosis. METHODS 619 time-respiratory (minute ventilation, tidal volume and respiratory rate) and 207 time-PaCO2 observations were obtained from 68 invasively ventilated COPD patients. We...

Results from a proposed equation for rebreathing systems, (formula: see text), were compared with results from a mechanical model "lung" ventilated either with a Bain Breathing Circuit, or a circle system (Eger-Ethans type A) without soda lime. When values for carbon dioxide excretion (VCO2), dead spacetidal volume ratio (VD/VT), minute volume ventilation (VE), and fresh gas flow (VF) were vari...

STUDY OBJECTIVE Data concerning inhaled nitric oxide (iNO) on pediatric ARDS is rare. We investigated the effects of iNO on pediatric ARDS in order to examine the ability to predict a response to iNO, the optimal concentration of iNO, the effects of < or = 1 ppm nitric oxide (NO), and the effect of iNO on PaCO2. SETTING ICU at Kumamoto (Japan) University Hospital. PATIENTS AND INTERVENTIONS...

Safe limits of time and temperature during sleep hypothermic circulatory arrest (DHCA) still remain controversial. Furthermore, continuous changes of PaO2, PaCO2, and pH have never been measured during DHCA in humans. Continuous intraarterial blood gas (CIABG) monitoring is a new technology allowing us to study chronological changes occurring due to metabolism during DHCA. When the patients' te...

Background: Bullous emphysema is characterized by destruction of lung parenchyma, reduction in elasticity of the lung, hyperinflation, and ventilation/perfusion mismatch. Ventilatory management of the patient with bullous emphysema is challenging, and especially so for the patient undergoing cardiac surgery. Case report: A 47-yearold man with severe diffuse bullous emphysema requested general a...

The independent effects of halothane and carbon dioxide on central mechanisms regulating respiratory frequency were investigated in 12 vagotomized, artificially ventilated cats. Changes in respiratory pattern analysed from the phrenic neurogram revealed that increasing PaCO2 at a constant depth of halothane anaesthesia caused a progressive increase in TE with various changes in TI, whereas incr...

Spontaneous periodic breathing, although a common feature in fullterm and preterm human infants, is scarce in other newborn mammals. The aim of this study was to induce periodic breathing in lambs. Four 10-day-old and two <48-h-old awake lambs were instrumented with jugular catheters connected to an extracorporeal membrane lung aimed at controlling arterial PCO2 (PaCO2). Arterial PO2 (PaO2) was...

BACKGROUND The analysis of arterial blood gas (ABG) is an invasive procedure that is used frequently in the emergency department (ED) to evaluate the acid-base status of critically-ill patients. However, capnometry is an alternative procedure that has been used in recent years to determine the metabolic status of patients' blood. Considering the correlation between end-tidal carbon dioxide (ETC...