Abstract:   Background: The most important and complex phenomenon of respiratory function of the nose is related to different nasal anatomy. The differences in facial anatomic structure between different races may also be reflected in nasal resistance and airflow. Caucasians has different facial anatomic structure which is the reflection of intranasal resistance or consequence of airflow. The...

background : adolescence is a critical developmental stage marked by complex transitions. the purpose of study was to assess school adolescents’ pwb, examine the relationship of pa and socio-demographic factors with pwb. methods : a cross sectional study conducted in five randomly selected schools with 345 adolescents (aged 12-18) from grade 6th-10th. a self-administered well-being index was ad...

To identify factors responsible for the decline of plasma tissue-type plasminogen activator (t-PA)-specific activity that we have observed after infusions of the activator and to define the potential usefulness of selected variants of t-PA in obviating them in patients with infarction, serial plasma samples from patients (n = 4) and rabbits (n = 15) given t-PA were assayed for total t-PA antige...

BACKGROUND Chronic thromboembolic pulmonary hypertension (CTEPH) is a disorder characterized by pulmonary arterial hypertension as a consequence of organized thrombotic material in the central pulmonary arteries. Incomplete resolution of acute pulmonary emboli is believed to be pathogenically important; however, the mechanism for poor thrombus dissolution remains to be explained. We undertook t...

in the neuroscience intensive care unit at the University of Virginia Health System in Charlottesville. properties of the fibrinolytic agent and the impact of adjuvant therapies such as antiplatelet and anticoagulant agents must also be considered. Tenecteplase is a variant of tissue plasminogen activator (t-PA) that is genetically engineered to have increased fibrin specificity, a longer half-...

The binding of tissue-type plasminogen activator (t-PA) to membranes prepared from human liver was investigated, and a specific, saturable, high-affinity binding site (Kd = 3.4 nM) was identified. The binding of t-PA to liver membranes was not affected by an excess of D-mannose or D-galactose, or by active urokinase (u-PA), whereas binding of t-PA to membranes prepared from human HepG2 hepatoma...