نتایج جستجو برای: p15 gene

تعداد نتایج: 1142253  

Journal: :Bosnian journal of basic medical sciences 2012
Dianliang Fang Yuanhong Guo Zhenshuang Zhu Weiqing Chen

The insensitivity of hepatocellular carcinoma to chemotherapy is associated with alternation in tumor cell cycling. This current study was designed to investigate the impact of p15 silencing on the sensitivity of Human hepatocellular carcinoma HepG2 cells to cisplatin. HepG2/CDDP/1.6 and HepG2/CDDP/2.0 cells were induced by culture with increased doses of cisplatin and their sensitivities to ci...

Journal: :Molecular cancer therapeutics 2007
Makoto Koyama Youichirou Matsuzaki Shingo Yogosawa Toshiaki Hitomi Mayumi Kawanaka Toshiyuki Sakai

Inactivation of the retinoblastoma protein pathway is the most common abnormality in malignant tumors. We therefore tried to detect agents that induce the cyclin-dependent kinase inhibitor p15(INK4b) and found that ZD1839 (gefitinib, Iressa) could up-regulate p15(INK4b) expression. ZD1839 has been shown to inhibit cell cycle progression through inhibition of signaling pathways such as phosphati...

2018
Christoph Sippl Steffi Urbschat Yoo Jin Kim Sebastian Senger Joachim Oertel Ralf Ketter

Promoter methylation of P15, P16, RB transcriptional corepressor 1 (RB1) and O-6-methylguanine-DNA methyltransferase (MGMT) impacts the prognosis of numerous glioma subtypes. However, whether promoter methylation of these genes also has an impact on the clinical course of pilocytic astrocytoma remains unclear. Using methylation-specific polymerase chain reaction, the methylation status of the t...

Journal: :The Journal of comparative neurology 2000
I B Kim E J Lee M K Kim D K Park M H Chun

The development of cholinergic cells in the rat retina has been examined with immunocytochemistry by using antisera against choline acetyltransferase (ChAT). ChAT-immunoreactive (IR) cells were first detected at embryonic day 17 (E17) in the transitional zone between the neuroblastic layer (NBL) and ganglion cell layer (GCL). At E20, ChAT-IR cells are located exclusively in the GCL. At postnata...

Journal: :Journal of neurology, neurosurgery, and psychiatry 1982
A D Wang L Symon F Gentili

Central conduction time following median nerve stimulation has been recorded in 28 patients with infratentorial space occupying lesions. Fourteen of these (50%) showed a prolonged central conduction time, which invariably involved that segment of the conduction time between the dorsal column nuclei generators and the generation site for P15, which we believe to be the upper brain stem or thalam...

Journal: :The EMBO journal 1999
J Katahira K Strässer A Podtelejnikov M Mann J U Jung E Hurt

Human TAP is an orthologue of the yeast mRNA export factor Mex67p. In mammalian cells, TAP has a preferential intranuclear localization, but can also be detected at the nuclear pores and shuttles between the nucleus and the cytoplasm. TAP directly associates with mRNA in vivo, as it can be UV-crosslinked to poly(A)+ RNA in HeLa cells. Both the FG-repeat domain of nucleoporin CAN/Nup214 and a no...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2012

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