During evolution, viruses have optimized the interaction with host factors to increase the efficiency of fundamental processes such as DNA replication. Bacteriophage 29 protein p1 is a membrane-associated protein that forms large protofilament sheets that resemble eukaryotic tubulin and bacterial filamenting temperature-sensitive mutant Z protein (FtsZ) polymers. In the absence of protein p1, p...

Streptococcus mutans is considered to be the major etiologic agent of human dental caries. Attachment of S. mutans to the tooth surface is required for the development of caries and is mediated, in part, by the 185-kDa surface protein variously known as antigen I/II, PAc, and P1. Such proteins are expressed by nearly all species of oral streptococci. Characteristics of P1 include an alanine-ric...

In a recent note, Santos proved that the number of partitions of n using only odd parts equals the number of partitions of n of the form p1 + p2 + p3 + p4 + . . . such that p1 ≥ p2 ≥ p3 ≥ p4 ≥ · · · ≥ 0 and p1 ≥ 2p2 + p3 + p4 + . . . . Via partition analysis, we extend this result by replacing the last inequality with p1 ≥ k2p2+k3p3+k4p4+. . . , where k2, k3, k4, . . . are nonnegative integers....

A sequence S is potentiallyKp1,p2,...,pt graphical if it has a realization containing aKp1,p2,...,pt as a subgraph, whereKp1,p2,...,pt is a complete t-partite graph with partition sizes p1, p2, ..., pt(p1 ≥ p2 ≥ ... ≥ pt ≥ 1). Let σ(Kp1,p2,...,pt, n) denote the smallest degree sum such that every n-term graphical sequence S with σ(S) ≥ σ(Kp1,p2,...,pt, n) is potentially Kp1,p2,...,pt graphical....

From the sequence of human IL-2 we have recently characterized a peptide (p1-30), which is the first IL-2 mimetic described. P1-30 covers the entire alpha helix A of IL-2 and spontaneously folds into a alpha helical homotetramer mimicking the quaternary structure of a hemopoietin. This neocytokine interacts with a previously undescribed dimeric form of the human IL-2 receptor beta-chain likely ...

The antimicrobial properties of cephalosporin P1, an antibiotic structurally related to fusidic acid, were examined. Cephalosporin P1 exhibited potent activity against methicillin-sensitive Staphylococcus aureus, methicillin-resistant S. aureus and vancomycin-intermediate S. aureus. Mutants of S. aureus resistant to cephalosporin P1 arose with a frequency of 1.6 x 10(-6) for selections at 4 x M...

OBJECTIVES P1 is a robust positivity at a latency of 50-150 msec in the auditory evoked potential of young children. It has been reported that over the first 2-3 years of life, there is a rapid decrease of the latency and the mean P1 latency in adults with normal hearing is approximately 60 msec. This study was designed to evaluate the change of the P1 latency in Koreans with normal hearing acc...

Expression of the LSP-2 and P1 genes was induced in cultured fat bodies of Drosophila third-instar larvae by supplementing the culture medium with ecdysterone. The fat bodies were isolated from ecdysterone-deficient larvae of the temperature-sensitive mutant ecd1, which were shifted from the permissive to the restrictive temperature either at the beginning of the third instar for the detection ...

Based on literature, it is possible to hypothesize that multidrug resistance (MDR) and angiogenic phenotypes are linked to each other in human liver cancer cells. Our goal is to assess whether MDR cells trigger angiogenesis and to study the possible molecular mechanisms involved. Conditioned medium from parental drug-sensitive P5 cells (P5-CM) and MDR-positive P1(0.5) cells [P1(0.5)-CM] stimula...