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Background: In 1988, the aspirin component of the Physicians’ Health Study, a randomized, double-blind, placebo-controlled trial of 22071 apparently healthy men was terminated early, due principally to a statistically extreme (P .00001) 44% reduction in the risk of a first myocardial infarction (MI). The Cardio-Renal Drugs Advisory Committee recommended that the US Food and Drug Administration ...
BACKGROUND Intra-articular normal saline (IA-NS) injections have been utilized as a placebo in a number of randomized controlled trials pertaining to the management of knee osteoarthritis (OA); however, it is believed that these "placebo" injections may have a therapeutic effect that has not been quantified in the literature. PURPOSE To (1) quantify the effect of IA-NS injections on patient-r...
Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen.
PURPOSE To conduct meta-analyses of randomized trials of aromatase inhibitors (AIs) compared with tamoxifen either as initial monotherapy (cohort 1) or after 2 to 3 years of tamoxifen (cohort 2). MATERIALS AND METHODS Data submitted to the Early Breast Cancer Trialists' Collaborative Group were used in separate meta-analyses of two cohorts. Primary analyses involve postmenopausal women with t...
cantly different (p<00001). Visual estimation of pupil size is accurate to about 0-2 mm' so detecting anisocoria of 0-5 mm or more presents no clinical difficulty. For practical purposes, therefore, miosis in the affected eye of a patient with unilateral red eye may indicate serious eye disease. We found that when an inflamed eye shows 0 5 mm or more miosis relative to the unaffected eye the pr...
BACKGROUND: Late-onset sepsis (LOS) is among the leading causes of morbidity and mortality in preterm newborns, and currently available diagnostic tools are inadequate. The objective of this study was to evaluate the accuracy of presepsin (P-SEP) as novel biomarker of bacterial infection for the diagnosis of LOS in preterm newborns. METHODS:We prospectively studied newborns#32 weeks’ gestationa...
: مطالعه‌ای حاضر با هدف تاثیر آموزش مهارت‌های حل مسئله بر شدت افسردگی زنان در دوره‌ی پس از زایمان انجام شد. روش‌کار: این کارآزمایی بالینی طی دی 1388 تا خرداد 1389 روی 54 زن در دوره‌ی پس از زایمان مراجعه‌کننده به مراکز بهداشتی مناطق دو و سه مشهد صورت گرفت. با داشتن معیارهای ورود به پژوهش، کسب نمره‌ی 10 و بالاتر از مقیاس افسردگی پس از زایمان ادینبورگ و نمره‌ی 28- 14 از پرسش‌نامه‌ی افسردگی بک و ...
Traffic policemen working in the busy traffic signal areas get exposed to the vehicular emissions for years together. The fumes, chemicals and particles present in the emission are reported to be damaging to the lung functions of these individuals. Since there were no data available on the PFT parameters of traffic police personnel of Pondicherry, this study was taken up to assess the effect of...
Abstract Aim Post-operative pain was a recurrent issue reported at the dressing clinic following local anaesthetic (LA) hand surgery our regional centre. In absence of protocol, we aimed to standardise advice and analgesic prescriptions LA observe whether could be more optimally managed. Method cycle 1, day 1 7 scores were recorded for ∼30 patients using validated visual analogue scale (VAS). 2...
latitude gradients and secular trends in europe and north america have been found in the male-female ratio at birth (M/f: male births divided by total births) which is expected to be 0.515. annual national data for Czechoslovakia and the post-Czechoslovakian (Czech Republic and slovakia) countries for male and female live births were obtained from the world health organisation and analysed with...
A high frequency (24%) of acute promyelocytic leukemia (APL) was noted among acute myelocytic leukemia (AML) cases at the Los Angeles County-University of Southern California (LAC-USC) Medical Center, in comparison with the expected frequency of 590 to 15%. Because of the high proportion of Latinos in this center, we questioned if APL is more common in this ethnic group. The proportion of APL a...
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