Mesosaurs are basal amniotes that lived at the beginning of Permian or close to Permo–Carboniferous boundary. Despite several hundred specimens have been found, including complete skeletons adult and juvenile individuals, mesosaur taxonomy has subjected a high controversy over time. Currently, three monotypic genera, Mesosaurus tenuidens Gervais, Stereosternum tumidum Cope, Brazilosaurus sanpau...

BackgroundContemporary practice patterns and outcomes for aortic valve replacement (AVR) among young middle-aged adults are unknown given guideline modifications surgical AVR (SAVR) increasing transcatheter (TAVR) acceptance. This study describes SAVR TAVR use using The Society of Thoracic Surgeons (STS) National Databases.MethodsAdults 18 to 55 years age in the Congenital Heart Surgery Databas...

Proline 3-hydroxylase was purified from Streptomyces sp. strain TH1, and its structural gene was cloned. The purified enzyme hydroxylated free L-proline to cis-3-hydroxy-L-proline and showed properties of a 2-oxoglutarate-dependent dioxygenase (H. Mori, T. Shibasaki, Y. Uosaki, K. Ochiai, and A. Ozaki, Appl. Environ. Microbiol, 62:1903-1907, 1996). The molecular mass of the purified enzyme was ...

To ascertain whether position 131 of a mesophilic protease, subtilisin BPN', is a potential critical site for cold adaptation as screened by evolutionary engineering (S. Taguchi, A. Ozaki, and H. Momose, Appl. Environ. Microbiol. 64:492-495, 1998), a full set of subtilisin BPN' mutants with mutations at position 131 was constructed by site-saturation mutagenesis. All mutated enzymes were measur...

S. Uehara, Y. Watanabe, I. Adachi, H. Aihara, K. Arinstein, A. M. Bakich, V. Balagura, E. Barberio, A. Bay, I. Bedny, K. Belous, V. Bhardwaj, U. Bitenc, A. Bondar, M. Bračko, T. E. Browder, M.-C. Chang, A. Chen, K.-F. Chen, W. T. Chen, B. G. Cheon, I.-S. Cho, Y. Choi, J. Dalseno, M. Dash, A. Drutskoy, S. Eidelman, D. Epifanov, B. Golob, 15 H. Ha, J. Haba, K. Hayasaka, H. Hayashii, Y. Hoshi, W.-...

In many cases of callosal dysgenesis in both human patients and mouse models, misguided fibers from the cortex form abnormal bilateral, barrel-shaped structures known as Probst bundles. Because little is known about how axons are arranged within these anomalous fiber bundles, understanding this arrangement may provide structural and molecular insights into how axons behave when they are misguid...

BackgroundAortic valve neocuspidization (AVNeo) for trileaflet aortic reconstruction using autologous pericardium (Ozaki procedure) offers an alternative treatment modality to overcome drawbacks of conventional prosthetic replacement.MethodsBetween October 2016 and April 2019, 103 patients underwent surgery. Mean follow-up was 426 ± 270 days. Aortic stenosis the leading diagnosis in 80 (77.7%) ...

Although considerable progress has been made in the understanding of the more "algebraic" properties of context-free languages, the quantitative aspects of the recognition and parsing of contextfree languages are still far from well understood. It was shown by Kasami and Younger that for every context-free language there exists a multitape Turing machine which recognizes this language and uses ...