Background The present study describes the susceptibility of prepubertal testis of mice to prooxidant induced oxidative impairments both under in vitro and in vivo exposure conditions. MaterialsAndMethods Following in vitro exposure to iron (5,10 and 25 M), oxidative response measured in terms of lipid peroxidation and hydroperoxide levels in testis of pre pubertal mice (4 wk) was more robust c...

The problem of time series motif discovery has received a lot of attention from researchers in the past decade. Most existing work on finding time series motifs require that the length of the motifs be known in advance. However, such information is not always available. In addition, motifs of different lengths may co-exist in a time series dataset. In this work, we develop a motif visualization...

It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total chole...

Delirium occurs in 23% of sepsis patients, in which pro-inflammatory cytokines and nitric oxide are suggested to be involved. However, in animal experiments, even a subseptic dose of lipopolysaccharide (LPS) injection induces both pro-inflammatory cytokines and inducible nitric oxide synthase in the brain, suggesting that the brain oxidative reaction can be induced in the subseptic condition. T...

The oxidative stability of margarine supplemented with different concentrations of fennel (Foeniculum vulgare) seed extract (FSE) was compared to the synthetic antioxidants; butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) at legal concentrations. The experiment was carried out under accelerated storage conditions for 4 weeks employing peroxide value (PV), p-anisidine value (AV...

Chronic administration of d-galactose (d-gal) in rodents reproduces the overproduction reactive oxygen species physiological aging. The present research shows for first time distinct signatures on d-gal-induced aging (500 mg/kg, 6 weeks) and preventive protective potential two vitamin D (50 IU) supplementation regimens (pre-induction simultaneous, respectively) vital organs (heart brain). notor...

Apoptosis induced by wild-type p53 or cytotoxic compounds in myeloid leukemic cells can be inhibited by the cytokines interleukin 6, interleukin 3, granulocyte-macrophage colony-stimulating factor, and interferon gamma and by antioxidants. The antioxidants and cytokines showed a cooperative protective effect against induction of apoptosis. Cells with a higher intrinsic level of peroxide product...