The 'oxidation theory' for atherosclerosis proposes that lipid and/or protein oxidation products are responsible for lesion formation/development. The major target for oxidation is suggested to be intimal low-density lipoprotein. This idea was stimulated by the pro-atherogenic properties of in vitro oxidized lipoproteins, such as stimulation of chemotaxis and sterol accumulation in macrophages,...

We addressed the role of class 1B phosphatidylinositol 3-kinase (PI3K) isoform PI3K in mediating NADPH oxidase activation and reactive oxidant species (ROS) generation in endothelial cells (ECs) and of PI3K -mediated oxidant signaling in the mechanism of NFB activation and intercellular adhesion molecule (ICAM)-1 expression. We used lung microvascular ECs isolated from mice with targeted deleti...

seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. despite the diversity in quality and quantity of the mediterranean tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...

results a significant higher serum pab value was observed in shift working and daytime nurses (152.28 ± 43.64 hk) in comparison to the control group (63.64 ± 34.41 hk index), p value = 0.001. in day time nurses, also serum pab between male (119.09 ± 47.14 hk) and female (162.53 ± 37.02 hk) in nursing workers was significant, p value = 0.005. in the night shift working nurses, there was also a s...

objective: crocin, the carotenoid isolated from saffron, has numerous medicinal properties which include anticancer and antioxidant activities. some antioxidants, such as carotenoids, can act as pro-oxidants at higher dosages and therefore induce tissue damage. in this situation antioxidant defense systems in the liver activate to prevent tissue damage. this study investigates the possible toxi...

objectives: iron chelators, such as maltol and kojic acid, have antioxidant and anti-inflammatory properties. they may have beneficial effects on inflammatory bowel disease (ibd) because iron can develop and aggravate inflammation in ibd. in the present study, the effect of selected iron chelators and anti-oxidants were evaluated on a model of trinitrobenzene sulfonic acid (tnbs)-induced coliti...

BACKGROUND Glucova Active Tablet is a proprietary Ayurvedic formulation with ingredients reported for anti-hyperglycemic, anti-hyperlipidemic activity and antioxidant properties. OBJECTIVE Evaluation of anti-diabetic activity of Glucova Active Tablet on Type I and Type II diabetic model in rats. MATERIALS AND METHODS Experimental Type I diabetes was induced in 24 albino rats with intra-peri...

Oxygen-derived free radicals are involved in the vascular response to angiotensin II (Ang II), but the role of NADPH oxidase, its subunit proteins, and their vascular localization remain controversial. Our purpose was to address the role of NADPH oxidase in the blood pressure (BP), aortic hypertrophic, and oxidant responses to Ang II by taking advantage of knockout (KO) mice that are geneticall...

The thiol/disulfide oxidoreductase DsbA is the strongest oxidant of the thioredoxin superfamily and is required for efficient disulfide bond formation in the periplasm of Escherichia coli. To determine the importance of the redox potential of the final oxidant in periplasmic protein folding, we have investigated the ability of the most reducing thiol/disulfide oxidoreductase, E.coli thioredoxin...