Abstract Background Breast cancer is known to be the most common in women; last decade, contrast-enhanced magnetic resonance imaging has become an important tool diagnosis of breast. Numerous studies have analyzed associations between and histopathological features as well proliferation potential breast cancer. The purpose this study was evaluate relationship apparent diffusion coefficient (ADC...

Purpose: To study the possible anti-cancer effects of miR-744 on human gastric cancer cells, and underlying mechanism.
 Methods: The mRNA expression was determined using qRT-PCR, while CCK-8, Annexin V/PI acridine orange assays were used to determine cell viability, apoptosis autophagy, respectively. expressions target proteins qRT-PCR Immunoblotting.
 Results: Significant suppression...

Abstract We have purified a novel caffeoylquinic acid named 3,4-di- O -caffeoylquinic isobutyl ester from the flower buds of Lonicera japonica Thunb., Caprifoliaceae. However, biological function is still unknown. Here, we found that effectively inhibited proliferation and migration hepatocellular carcinoma cells, it displayed less toxicity to normal liver cell line. Mechanistic studies showed ...

The study of fruit development in zucchini via gene expression has proven to be applicable breeding programs. Phenotypic and transcriptomic studies set parthenocarpy have been previously developed some relevant genes reported. From these studies, three genotypes (MUCU-16, Whitaker, Cavili) six (CpAUX22, CpIAA4, CpIAMT-1, CpPIN5, CpCYCD6-1, CpEXPLB1) were selected. was analyzed each genotype und...

Heart failure (HF) is a cardiovascular disease with complex pathological pathway and influenced by many factors. Such mechanism would impair cardiac function structural stability. One that plays role in maintaining the structure of heart extracellular matrix (ECM), disruption has causing dysfunction. ECM regulation associated metalloproteinase (MMP). Overexpression metalloproteinases can lead t...


 Purpose: To evaluate the role of miR-20a in sevoflurane (SEV)-induced cognitive impairment rats and to elucidate mechanism action.
 Methods: A SEV-induced rat model was developed. The Morris water maze test fear assay were carried out assess impaired learning memory. cellular SEV-impaired developed level measured animal models. TUNEL staining immunoblot performed determine SEV effec...

background and aim: micro rnas are a group of small non-coding rnas which play an important role in multiple processes such as proliferation, differentiation, apoptosis, and cancer. recent studies indicate that mir-210 is overexpressed into erythroid linage during the differentiation of hematopoietic precursor. the main goal of the present study is to investigate the influence of mir-210 on the...

breast cancer affects iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in tehran. thisstudy aimed to compare the ahr levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. possible associations of ahr with lifestyle and reproductive risk factorsand ...

conclusions this study on a limited number of patients treated with adjutant anthracyclins-based regimens, revealed that her2/neu is not a unique strong predictor for outcome, thus according to combination of her2/neu status and other clinical factors, it is necessary to distinguish patients at high risk of recurrence. results her2/neu amplification was identified in 19 (38%) of 50 patients. no...