BACKGROUND Parabens are preservatives commonly used in personal care products, pharmaceuticals, and foods. There is documented widespread human exposure to parabens, and some experimental data suggest that they act as estrogenic endocrine disruptors. As far as we are aware, no epidemiologic studies have assessed female reproductive health effects in relation to paraben exposure. OBJECTIVE We ...

BACKGROUND Cancer is widely believed to result from chronic inflammation, and red cell distribution width (RDW) and mean platelet volume (MPV) are considered as inflammatory markers for cancer. We investigated the values of RDW, MPV, and cancer antigen 125 (CA125), alone or in combination, for distinguishing between ovarian cancer and benign ovarian tumors. METHODS The study included 326 pati...

Ultrasonography is the method of choice in the diagnosis of ovarian cysts. In this case report, a cyst of enormous volume (>35 litres) was limiting the application of ultrasound techniques giving the false impression of ascites. A 55-year-old woman was finally diagnosed as having a giant ovarian mucosal-serosal cystadenoma of borderline potential after undergoing a total abdominal hysterectomy ...

It is unarguable that residual tumor volume after primary cytoreductive surgery is the best prognostic factor in clinical course of epithelial ovarian cancer [1]. Nowadays, residual tumor volume does not only predict patients' prognosis but also guides adjuvant treatment strategy including application of targeting drugs. Thus, a growing number of current clinical trials are selecting or stratif...

Ovarian cancer is the most fatal gynecologic cancer with poor prognosis. Etiological factors underlying ovarian cancer genesis and progression are poorly understood. Previously, we have shown that JNK-associated Leucine zipper Protein (JLP), promotes oncogenic signaling. Investigating the role of JLP in ovarian cancer, our present study indicates that JLP is overexpressed in ovarian cancer tiss...

Over the last 40 years, the age-adjusted ovarian cancer mortality rate in the USA declined by 23%. The decline in mortality paralleled a decline in incidence, which was largely due to changes in reproductive risk factors. There was no reduction in ovarian cancer case-fatality at 12 years, indicating that improvements in early detection or in treatment did not contribute to the decline in mortal...

Thyroid gland dysfunction is associated with disorders of female reproductive functions. The aim of this study was to examine the effects of hyperthyroidism on ovulation rate and peripheral sex steroid levels in prepubertal and adult rats. Two groups of female rats aging 30 days (prepubertal rats) and 60 days (adult rats) were made hyperthyroid by oral administration of levothyroxine daily...