BACKGROUND Ovarian tissue cryopreservation is a promising technique to safeguard fertility in cancer patients. However, in some types of cancer, there is a risk of transmitting malignant cells present in the cryopreserved tissue. To avoid such a risk, pre-antral follicles could be isolated from ovarian tissue and grown in vitro. On the basis of this assumption, the aim of our study was to inves...

OBJECTIVE To evaluate the safety and risk of cryopreservation in female fertility preservation. DATA SOURCES The data analyzed in this review were the English articles from 1980 to 2013 from journal databases, primarily PubMed and Google scholar. The criteria used in the literature search show as following: (1) human; embryo; cryopreservation/freezing/vitrification, (2) human; oocyte/immature...

Transplantation of cryopreserved ovarian tissue is a technology that holds promise for preserving reproductive potential for the future. It may be apropos for cancer survivors who will undergo treatment with sterility-inducing chemotherapy or radiation. Although there is some evidence suggesting cellular and molecular injury with the freezing and thawing process, there are examples in both anim...

In 2010, there were an estimated 730,000 new cancer cases in females, resulting in approximately 270,000 deaths [ 1 ] . Although malignancy remains a critical health concern, signi fi cant medical advances in cancer detection and treatment have improved survival rates for patients. Gonadotoxic chemotherapy or radiation for malignant disease may result in altered ovarian function, affecting both...

As the chapters in this volume demonstrate, like other nascent medical technologies ovarian tissue cryopreservation (OTC) raises no earth-shatteringly new moral questions. Rather, it poses old moral questions in new ways, thus shedding light not only on our old answers but also on our old methods of reaching them. My task here is to point out the ways in which OTC forces us to embrace important...

With the evolution of the treatment of malignant neoplasms, the survival rates of patients undergoing chemo- or radiotherapy are increasing. The continuous development of techniques of assisted human reproduction has led to important strategies in an attempt to maintain reproductive function in patients subjected to treatment of neoplastic diseases, among them cryopreservation of embryos, gamet...

Background: The aim of this study was to evaluate the efficacy of a vitrification protocol developed by our group to cryopreserve ovarian tissue. For this, we used ovaries from non-human primates in order to have an animal model close to the clinical setting. Materials and Methods: Ovarian biopsies from five adult baboons were vitrified, warmed and autografted. After five months, follicle survi...

to the editor: Premenopausal women who undergo high-dose chemotherapy have a very high risk of ovarian failure. 1 Cryopreservation of ovarian tissue with subsequent autotransplantation has effectively preserved fertility in an animal model, 2 but its efficacy in humans has been uncertain. Eggs that were aspirated from cryopreserved ovarian tissue transplanted in heterotopic sites did not result...

BACKGROUND Cryopreservation of ovarian tissue has been widely accepted as an option for fertility preservation among cancer patients. Some patients are exposed to chemotherapy prior to ovarian tissue cryopreservation. Consequently, assessment of the developmental capacity of human ovarian tissue after chemotherapy is of primary importance. MATERIALS In order to study the impact of previous ch...