Introduction. Sexual dimorphism with an increased prevalence in women has long been observed in various autoimmune, allergic, and skin diseases. Recent research has attempted to correlate this female predilection to physiologic changes seen in the menstrual cycle in order to more effectively diagnose and treat these diseases. Cases. We present five cases of cutaneous diseases in women with annu...

Early menopause or premature ovarian insufficiency (POI) is a common cause of infertility in women and affects about one per cent of young women. This disorder has significant psychological sequelae and major health implications. Its relevance has increased in recent years due to the fact that age of motherhood is being delayed in developed countries, with the risk of having either primary ovar...

Objective: Ovarian cancer is the most deadly in women, ranking fourth among all fatal diseases women. Conventional chemotherapy has its own plethora of challenges, such as side effects and disease relapse. Hydroxyurea a type anticancer drug that commonly used to treat malignancies. This study aims develop optimize hydroxyurea nanostructured lipid carriers (NLCs) improve therapeutic index reduce...

Ovarian cancer is one of the most common cancers in women. Its early stages may be asymptomatic, and as a result diagnosis frequently occurrs at an advanced, often incurable, stage. The high mortality and low survival rates associated with ovarian cancer can in part be attributed to the lack of diagnostic methods allowing for early detection, yet a methodology to identify patients with early-st...

Over the history of medicine, man has developed effective ways to treat many diseases that he has been presented with. The treatments range from prevention in the form of vaccination to the use of medicines and surgical intervention as cures or even treatments to control the diseases effect on the patients’ quality of life. For many diseases, such as heart disease and cancer, early detection pl...

Women at increased risk for breast cancer are at increased risk for ovarian cancer as well, reflecting common risk factors and intertwined etiology of the two diseases. We previously developed a rat model of elevated breast and ovarian cancer risk, allowing evaluation of dual-target cancer prevention strategies. Tamoxifen, a Food and Drug Administration-approved breast cancer chemoprevention dr...

BACKGROUND The production of ascites is a common complication of ovarian cancer. Ascites constitute a unique tumor microenvironment that may affect disease progression. In this context, we recently showed that ovarian cancer ascites may protect tumor cells from TRAIL-induced apoptosis. In this study, we sought to determine whether the prosurvival effect of ascites affects disease-free intervals...

Ovarian cancer is the deadliest of the gynecological diseases and the fifth cause of cancer death among American women. This is mainly due to the lack of prognostic tools capable of detecting early stages of ovarian cancer and to the high rate of resistance to the current chemotherapeutic regimens. In this scenario the overall 5-year survival rate for ovarian cancer patients diagnosed at late s...