For the semester project, we are aiming to develop an intuitive, haptic interface that will allow for improved control over a surgical manipulator designed for application in removal of osteolysis. Current surgical options for osteolysis removal require manual surgery that often leaves much of the lesion unexplored, and, thus, researchers at the Applied Physics Lab and Johns Hopkins University ...

Wear debris causes biological response which can result in periprosthetic osteolysis after total joint replacement surgery. Nuclear factor-kappa B (NFκB), a representative transcription factor involved in inflammation, is believed to play an important role in this event by regulating the production of proinflammatory mediators and osteoclastogenesis. In this study, we sought to determine whethe...

Total hip replacement has consistently been shown to be one of the most reliable and successful surgical procedures in orthopaedic surgery . However time, the longevity of total hip replacement implants may be limited by osteolysis and aseptic loosening regardless of the method of fixation . Osteolysis manifests itself by causing progressive periprosthetic bone resorption secondary to the biolo...

The RANKL-induced NF-κB signaling pathway is required for osteoclast formation and function. By screening for compounds that inhibit RANKL-induced NF-κB activation using a luciferase reporter gene assay in RAW264.7 cells, we identified triptolide (PG490), as a candidate compound targeting osteoclast differentiation and osteoclast-mediated osteolysis. Triptolide (PG490) is an active compound of ...

There are many causes of inflammatory osteolysis, but regardless of etiology and cellular contexts, the osteoclast is the bone-degrading cell. Thus, the impact of inflammatory cytokines on osteoclast formation and function was among the most important discoveries advancing the treatment of focal osteolysis, leading to development of therapeutic agents that either directly block the bone-resorpt...

We retrospectively reviewed, ten years after surgery, 100 consecutive total hip replacements in which the Duraloc 300 cup had been used. Post-operative radiographs were analysed for placement of the cup and interface gaps and follow-up radiographs for lucent lines, osteolysis, wear and migration. All the components were found to be stable with no evidence of loosening. The mean rate of wear was...

BACKGROUND Wear particle-induced peri-implant loosening is the most common complication affecting long-term outcomes in patients who undergo total joint arthroplasty. Wear particles and by-products from joint replacements may cause chronic local inflammation and foreign body reactions, which can in turn lead to osteolysis. Thus, inhibiting the formation and activity of osteoclasts may improve t...

Wear particle-induced osteolysis is a major cause of aseptic loosening, which is one of the most common reasons for total hip arthroplasty (THA) failure. Previous studies have shown that the synovial fibroblasts present in the periprosthetic membrane are important targets of wear debris during osteolysis. However, the interaction mechanisms between the wear debris and fibroblasts remain largely...

Aseptic loosening and periprosthetic osteolysis are major problems in artificial hip joint surgery,for which a solution has yet to be found. Biological host response to wear debris combined with cyclic mechanical loading onto the bone bed around hip prosthetic implants has been considered as mechanism responsible for implant-mediated periprosthetic osteolysis. Any type of artificial joint glidi...