نتایج جستجو برای: osteocytes

تعداد نتایج: 2034  

2012
Takeshi Moriishi Ryo Fukuyama Masako Ito Toshihiro Miyazaki Takafumi Maeno Yosuke Kawai Hisato Komori Toshihisa Komori

Reduced mechanical stress is a major cause of osteoporosis in the elderly, and the osteocyte network, which comprises a communication system through processes and canaliculi throughout bone, is thought to be a mechanosensor and mechanotransduction system; however, the functions of osteocytes are still controversial and remain to be clarified. Unexpectedly, we found that overexpression of BCL2 i...

Journal: :Bone 2000
K Kusuzaki N Kageyama H Shinjo H Takeshita H Murata S Hashiguchi T Ashihara Y Hirasawa

We recently found that silver impregnation staining with protargol (silver protein), that is, a modified Bodian method, is useful for histologically identifying the details of bone canaliculi structure, using thin sections of decalcified bone tissues. With this staining method, we conducted the present study to assess the development of bone canaliculi during the process of intramembranous ossi...

2007
Lennart Krook

Since serum alkaline phosphatase increases in fluoride therapy for osteoporosis, it is generally accepted that fluoride stimulates bone formation. However, histochemical studies have shown that alkaline phosphatase is also increased in resorbing osteocytes. Fluoride is toxic to metabolically active bone cells, alkaline phosphatase is released, and serum alkaline phosphatase increases. We propos...

2015
Myles Wolf

Purpose of review—High levels of fibroblast growth factor 23 (FGF23) cause rare disorders of hypophosphatemic rickets and are a risk factor for cardiovascular disease and death in patients with chronic kidney disease (CKD). Despite major advances in understanding FGF23 biology, fundamental aspects of FGF23 regulation in health and in CKD remain mostly unknown. Recent findings—Autosomal dominant...

2011
Yumie Rhee Matthew R Allen Keith Condon Virginia Lezcano Ana C Ronda Carlo Galli Naomi Olivos Giovanni Passeri Charles A O'Brien Nicoletta Bivi Lilian I Plotkin Teresita Bellido

The periosteal and endocortical surfaces of cortical bone dictate the geometry and overall mechanical properties of bone. Yet the cellular and molecular mechanisms that regulate activity on these surfaces are far from being understood. Parathyroid hormone (PTH) has profound effects in cortical bone, stimulating periosteal expansion and at the same time accelerating intracortical bone remodeling...

2013
Jason M. Graham Bruce P. Ayati Sarah A. Holstein James A. Martin

Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling. However, there is increasing evidence that osteocytes play ...

Journal: :The Journal of endocrinology 2007
Christianne M A Reijnders Nathalie Bravenboer Annechien M Tromp Marinus A Blankenstein Paul Lips

Mechanical loading plays an essential role in maintaining skeletal integrity. Mechanical stimulation leads to increased bone formation. However, the cellular and molecular mechanisms that are involved in the translation of mechanical stimuli into bone formation, are not completely understood. Growth factors and osteocytes, which act as mechanosensors, play a key role during the bone formation a...

Journal: :Advanced Healthcare Materials 2021

During bone remodeling, osteoblasts are known to deposit unmineralized collagenous tissue (osteoid), which mineralizes after some time lag. Some of the differentiate into osteocytes, forming a cell network within lacunocanalicular (LCN) bone. To get more insight potential role osteocytes in mineralization process osteoid, sites formation three-dimensionally imaged nine human osteons using focus...

Journal: :Journal of musculoskeletal & neuronal interactions 2002
F R Bringhurst

Osteocytes comprise a heterogenous population of terminally differentiated osteoblasts that direct bone remodeling in response to applied mechanical loading of bone. Increased osteocyte density accompanies the anabolic effect of PTH in vivo, whereas accelerated osteocyte death may be precipitated by estrogen deficiency or excess glucocorticoid exposure (conditions benefitted by intermittent PTH...

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