Introduction: The structure and the neural control of the upper airway have evolved to serve four important physiological functions: 1) respiration 2) deglutition 3) speech and 4) local immunity. The upper airway is collapsible in order to accommodate these functions. During wakefulness, upper airway collapse can be prevented by an increase in pharyngeal neuromuscular tone (1). However, this me...

BACKGROUND Obstructive sleep apnea-hypopnea syndrome (OSAS) is associated with elevated liver enzymes and fatty liver. The purpose of this study was to measure serum liver enzyme levels in patients evaluated by polysomnography (PSG) and the factors associated with liver injury in OSAS patients. METHODS All patients referred to PSG for evaluation of sleep apnea symptoms between June 2011 and N...

OBSTRUCTIVE SLEEP APNEA SYNDROME (OSAS) IS A COMMON DISEASE THAT OCCURS IN ABOUT 2% TO 4% OF THE GENERAL POPULATION.1,2 PATIENTS WITH OSAS suffer from hypoxemia and hypercapnia during sleep caused by repetitive nocturnal respiratory pauses. Moreover, nocturnal hypoxemia is considered to be associated with cardiovascular and cerebrovascular disease,3,4 although the association has not been fully...

STUDY OBJECTIVES To better characterize the cognitive deficits observed in obstructive sleep apnea syndrome (OSAS) by examining procedural skill learning abilities. DESIGN Procedural skill learning was assessed using Mirror Tracing and Rotary Pursuit skill learning tasks. Subjects also completed a comprehensive neuropsychological test battery. SETTING Cognitive testing was performed during ...

INTRODUCTION Recurrent hypoxia, which is associated with obstructive sleep apnea syndrome (OSAS), leads to an increase in the degradation of adenosine triphosphatase into xanthine, which in turn increases uric acid concentrations. OBJECTIVE The current study aimed to determine whether an association exists between OSAS and uric acid levels in the peripheral blood from a representative populat...

OBJECTIVES The pathophysiological links between obstructive sleep apnea syndrome (OSAS) and cardiovascular mortality are incompletely understood. We aimed to contribute to a better characterization by using comprehensive biomarker profiling quantifying hemodynamic cardiac stress, cardiomyocyte injury, inflammation, endothelial function, matrix turnover and metabolism. DESIGN AND METHODS In 65...

In the current issue of Respiration, an investigation of 100 subjects with OSAS did not find a correlation between oxygen desaturation or the apnea/hypopnea index and VEGF level. Instead, there was a greater correlation between subject age and VEGF level [6] . That studies yield differing results as to whether a relationship exists between OSAS and VEGF level should not be viewed as surprising....

OBJECTIVE Small upper airway measurements areas and high body mass index are recognized risk factors for obstructive sleep apnea syndrome (OSAS) in non-elderly populations; however, there is limited information regarding elderly patients. We evaluated whether upper airway volume is associated with OSAS and OSAS treated with continuous positive airway pressure (CPAP) treatment and whether BMI is...

We meta-analytically summarized the associations of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with ACE activity and obstructive sleep apnea syndrome (OSAS) to see whether ACE activity is causally associated with OSAS. Literature search and data abstraction were done in duplicate. Sixteen articles including 2060 OSAS patients and 1878 controls were summarized...

There are little information on prevalence of obstructive sleep apnea syndrome (OSAS) and clinical features in the young military population. The purpose of this study was to estimate the prevalence of snoring and high risk of OSAS in young male soldiers in Korea and to identify the risk factors of OSAS. A total of 665 participants (aged 20-23 yr) who visited the Armed Forces Ildong Hospital fo...