نتایج جستجو برای: orthopoxvirus
تعداد نتایج: 519 فیلتر نتایج به سال:
Infeksi virus monkeypox (virus MPX) atau dikenal sebagai penyakit cacar monyet merupakan infeksi zoonosis endemik. Virus MPX termasuk dalam genus Orthopoxvirus, DNA beruntai ganda yang diidentifikasi pertama kali pada tahun 1970, dan menjadi endemik di Afrika Tengah Barat. Transmisi dapat melalui kontak langsung tidak langsung. Pada awal 2022, telah tersebar keluar dari negara-negara Afrika. Ta...
Smallpox was the first human disease to be eradicated, through a concerted vaccination campaign led by the World Health Organization. Since its eradication, routine vaccination against smallpox has ceased, leaving the world population susceptible to disease caused by orthopoxviruses. In recent decades, reports of human disease from zoonotic orthopoxviruses have increased. Furthermore, multiple ...
Interest in airborne smallpox transmission has been renewed because of concerns regarding the potential use of smallpox virus as a biothreat agent. Air disinfection via upper-room 254-nm germicidal UV (UVC) light in public buildings may reduce the impact of primary agent releases, prevent secondary airborne transmission, and be effective prior to the time when public health authorities are awar...
This article examines the biosecurity and biodefense implications resulting from the recent creation of horsepox virus, a noncirculating (extinct) species of orthopoxvirus. Here we examine the technical aspects of the horsepox virus synthesis and conclude that orthopox synthesis experiments currently remain technically challenging-and will continue to be so, even once this work is published in ...
Motivation: Orthopoxviruses are a large group of closely related viruses displaying a high homology of their genomic nucleotide sequences. These viruses differ also in the severities of the diseases they cause and have different host ranges. Evolutionary relationships of various orthopoxvirus species are yet vague (Marennikova, Shchelkunov, 1998). Results: Analysis of the structures of importan...
ST-246, a potent orthopoxvirus egress inhibitor, is safe and effective at preventing disease and death in studies of small-animal models involving challenge by several different pathogenic poxviruses. In this report, the antiviral efficacy of ST-246 in treatment of nonhuman primates infected with variola virus or monkeypox virus was assessed. The data indicate that oral dosing once per day with...
Vaccinia virus naturally circulates in Brazil and is the causative agent of a zoonotic disease known as bovine vaccinia (BV). We retrospectively evaluated two populations from the Amazon and Southeast Regions. BV outbreaks had not been reported in these regions before sample collection. Neutralising antibodies were found in 13 individuals (n = 132) with titres ranging from 100 ≥ 6,400 neutralis...
As a surrogate for 4'-hydroxy-5'-noraristeromycin and related carbocyclic nucleosides, an efficient, enantiodivergent synthetic route to both enantiomers of 5-(6-amino-9H-purin-9-yl)-3,3-difluorocyclopentane-1,2-diol (6 and ent-6) has been developed from a common starting material ((+)-(1R,4S)-4-hydroxy-2-cyclopenten-1-yl acetate, 10). Both compounds were assayed versus a series of viruses. The...
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