BACKGROUND The efficacy of antibiotics in preventing surgical site infections (SSIs) depends on the timing of administration relative to the start of surgery. However, currently, both the timing of and recommendations for administration vary substantially. AIM To determine how the economic value from the hospital perspective of preoperative antibiotics varies with the timing of administration...

orthopaedic procedures. In the unlikely event of contamination of the system, deep wound infection could occur, jeopardising the operation. We have prospectively studied 50 patients who underwent elective and orthopaedic trauma procedures during which a suction system was used. At the end of each procedure the suction catheter tip was sent for culture and microbiology. The suction tips showed b...

BACKGROUND Although nasal carriage of MRSA has been identified as one of the risk factors for surgical site infection (SSI) with MRSA, there have been no reports of this in the orthopedics field. METHODS This prospective observational cohort study included 2,423 consecutive patients who were admitted to our department over 26 months and who underwent orthopedic surgery. We examined the relati...

In this study, 32 osteosarcoma patients admitted in the department of orthopedics from 2008 to 2016 were selected as subjects. Percutaneous intra-arterial chemotherapy was performed on 17 patients on the day before admission, and then the general chemotherapy was carried out on next day. After limb salvage surgery, the previous chemotherapy was repeated for 4 times. Before limb salvage surgery,...

Pseudoaneurysms (PSA) of deep femoral artery (DFA) have been reported following penetrating and blunt trauma to the thigh and orthopedic procedures of the proximal femur. We describe a case of pseudoaneurysm of DFA as a late complication of limb trauma which was confirmed by exploration in an urgent surgery. After two operations successful surgical repair was performed.

398. Pharmacokinetics of dalbavancin (DAL) in bone and associated tissues in patients undergoing orthopedic surgical procedures James Baldassarre, MD; Scott Van Wart, MS; Alan Forrest, PharmD; Christopher Rubino, PharmD; Michael Dunne, MD; Durata Therapeutics, Branford, CT; Institute for Clinical Pharmacodynamics, Latham, NY; University at Buffalo School of Pharmacy and Pharmaceutical Sciences,...

Antibiotic Loaded Tissue Sealant for the Prevention of Postoperative Infection in Orthopedic Procedures Kevin Letchford1, Clement Mugabe1, Jody Cashman2, Kate Ball3, John Jackson1, Helen Burt1 1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; 2Angiotech Pharmaceuticals, Inc., Vancouver, BC, Canada; 3Department of Orthopedics, Vancouver General Hospital,...

We investigated the proportion of orthopaedic procedures supported by evidence from randomised controlled trials comparing operative procedures to a non-operative alternative. Orthopaedic procedures conducted in 2009, 2010 and 2011 across three metropolitan teaching hospitals were identified, grouped and ranked according to frequency. Searches of the Cochrane Central Register of Controlled Tria...