Abstract Neuropathic pain induced by chemotherapy drugs such as oxaliplatin is a dose-limiting side effect in cancer treatment. The mechanisms underlying chemotherapy-induced neuropathic pain are not fully understood. KCNQ2 channels are low-threshold voltage-gated K+ channels that play a role in controlling neuronal excitability. Downregulation of KCNQ2 channels has been proposed to be an under...

Background Orofacial clefts are among the most common congenital craniofacial malformations and may be associated with other birth defects. However, the proportion and type of additional anomalies vary greatly between studies. This study assessed the prevalence and type of associated congenital malformations in children with orofacial clefts, who attended the largest cleft lip and palate tertia...

Studies using nonhuman primates have made marked contributions to our understanding of the anatomy and function of the primary somatosensory cortex (SI). Its ventral or inferolateral part (vSI) represents orofacial structures, such as the lips, periodontium, tongue, palate, chewing musculature, etc. This brain region is neurally interconnected with the ventral part of the primary motor cortex t...

The aims of the present study were to assess the influence of: a) trait anxiety on orofacial pain; and b) orofacial pain on state anxiety. Forty-four rats were initially exposed to the free-exploratory paradigm for the evaluation of their anxiety profiles. In accordance to the parameter "Percentage of time in the novel side", the animals were considered as presenting high or low levels of trait...

AIM Using functional scales and face video analysis, changes in central facial paresis are monitored in patients with stroke after orofacial therapy and correlations between changes in mimicry, mental function and overall quality of life of patients after stroke are made. MATERIALS AND METHODS A prospective randomized study of patients after stroke with facial paresis. The functional status o...

introduction: the american academy of orofacial pain defined temporomandibular disorders (tmds) as”a collective term that embraces a number of clinical problems that involve the masticatory muscles, the tmj (temporomandibular joint), and the associated structures”. pain and dysfunctional symptoms or signs such as limitations in opening, asymmetric jaw movements and tmj sounds are the most commo...

Although rare, Eagle syndrome should be always considered in the differential diagnosis in patients with chronic orofacial pain refractory to conventional treatments. Treatment is surgery and exeresis of the styloid process via a transoral or cervical approach depending on clinical and radiological features.

BACKGROUND Cerebral palsy (CP) is the main cause of severe physical impairment during childhood and has commonly shown oral motor association. It has been considered as the main cause of the high prevalence of problems in children's nutrition. Respiration, chewing, swallowing, speaking and facial expressionare part of the orofacial motor functions and when affected they can interfere in childre...