During cancer metastasis, circulating tumor cells constantly experience hemodynamic shear stress in the circulation. Cellular responses to shear stress including cell viability and proliferation thus play critical roles in cancer metastasis. Here, we developed a microfluidic approach to establish a circulatory microenvironment and studied circulating human colon cancer HCT116 cells in response ...

Many wall-bounded turbulent flows are characterized by a complex interaction between the outer shear layer, the structure of which is similar to a free shear layer, and an inner layer, which is essentially a perturbed boundary layer. Examples in which such an interaction occurs are separated flows recovering from reattachment, wall jets used in the context of wall cooling, heating and separatio...

Wall-shear stress results from the relative motion of a fluid over a body surface as a consequence of the no-slip condition of the fluid in the vicinity of the wall. To determine the two-dimensional wall-shear stress distribution is of utter importance in theoretical and applied turbulence research. In this article, characteristics of the Micro-Pillar Shear-Stress Sensor MPS(3), which has been ...

Arterial wall shear stress is widely believed to influence the formation and growth of atherosclerotic plaque; however, there is currently no gold standard for its in vivo measurement. The use of phase contrast MRI has proved to be challenging due to partial-volume effects and inadequate signal-to-noise ratio at the high spatial resolutions that are required. This work evaluates the use of spir...

The significance of incorporating soil-structure interaction effect in the analysis and design of RC frame buildings is increasingly recognized but still not penetrated to the grass root level owing to various complexities involved. It is well established fact that the soil-structure interaction effect considerably influence the design of multi-storey buildings subjected to lateral seismic load...

metal spinning as a kind of manufacturing process has capability to shape hollow components. in present work shear spinning process is used to formplates into conical shapes. moreover, the aim of this research is to demonstrate the impact of the process parameters (i.e. feeding rate and spindle speed) on wall thickness. this approachwas done by experimental and finite elements method. the resul...

Engineering judgement and intuition are vital characteristic of the design profession. Engineering judgement and intuition are developed through experience. This experience is gained by designing a building (working with industry disciplines and the owner); analyzing the building (calculations); being part of the construction process (constructability), and walking through the final product (en...

the purpose of this research is to numerically investigate the interaction of pulsatile flow of blood with an axisymmetric artery in various percentages of stenosis. the carreau non-newtonian model and the generalized maxwell rheological model were used to model the blood fluid and the viscoelastic wall of arterial, respectively. the innovation of the present research is modeling of viscoelasti...

We describe a simple method for estimating wall friction which uses the fit of velocity data to the boundary layer profile in wall units all the way from the wall to the end of the log region. Two different models for the boundary layer profile are examined, the power-series interpolation scheme of Spalding and the Musker profile which is based on the eddy viscosity concept. The accuracy of the...