BACKGROUND AND OBJECTIVES Superficial fungal skin infections are treated using topical antifungals. The aim of this study was to demonstrate the efficacy of a single application of 1 % terbinafine film-forming solution (FFS) versus placebo for the treatment of tinea pedis in the Chinese population. METHODS Six centers in China randomized 290 patients in a 1:1 ratio to receive either 1 % terbi...

OBJECTIVE To evaluate the effect of short term treatment with terbinafine on dermatophytosis. DESIGN Multicentre, randomised, double blind placebo controlled trial of 250 mg/day terbinafine for 12 weeks in dermatophyte onychomycosis. SETTING Eight dermatology centres in the United Kingdom. PATIENTS 112 patients (mean age 44, range 19-78), 99 with mycologically proved toenail infections an...

BACKGROUND Effective treatment of tinea pedis and onychomycosis is crucial for patients with diabetes as these infections may lead to foot ulcers and secondary bacterial infections resulting in eventual lower limb amputation. Although numerous studies have assessed the effectiveness of antifungal drug and treatment regimens, most exclude patients with diabetes and examine otherwise healthy indi...

There has only been one clinically confirmed case of terbinafine resistance in dermatophytes, where six sequential Trichophyton rubrum isolates from the same patient were found to be resistant to terbinafine and cross-resistant to other squalene epoxidase (SE) inhibitors. Microsomal SE activity from these resistant isolates was insensitive to terbinafine, suggesting a target-based mechanism of ...

We report here the first case of neonatal tinea faciei caused by Trichophyton tonsurans in mainland China. The mother of the infant had tinea corpris and tinea capitis while the father had tinea incongnito. The infections in the parents were mycologically confirmed to be due to Trichophyton tonsurans. Ttinea faciei in the infant was cured after two-week topical use of amorolfine cream. The moth...

A 54 year old female was hospitalised with anti-microbial-sensitive H. influenza pneumonia, her first major infection. Past medical history included prior motor vehicle accident, 160 pack year history of smoking and a recent diagnosis of chronic obstructive pulmonary disease (COPD). Medications on admission were Budesonide-Efomoterol, terbinafine and bupropion. There was no history of allergy, ...

* Tinea pedis (athlete's foot) occurs in about 15% ofthe population * Its usual treatment is a topical antifungal applied two or three times a day for up to four weeks * Terbinafine is a synthetic allylamine antifungal with a primarily fungicidal action against dermatophytes and some other moulds and yeasts * This study shows that terbinafine 1% cream applied twice daily for a week was signific...

backgrounds candida vaginitis is a common fungal infection among adult women and it has been estimated that 75% of all adult women experience at least one period of vulvovaginal candidiasis in their lifetime. several predisposing factors, such as diabetes mellitus,using contraceptive, pregnancy, and broad-spectrum antibiotics are reported as main risk factors for the infection. while, the main ...