A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea. advancement devices in 630 men and women with obstructive sleep apnea and snoring: tolerability and predictors of treatment success. Assessment of upper airway dynamics in awake sleep apnea patients wi...

We investigated whether plasticity of human motor cortex (M1) is influenced by time of day, and whether changes in circulating levels of cortisol contribute to this effect. Neuroplasticity was induced using paired associative stimulation (PAS), involving electrical stimulation of left median nerve, paired with transcranial magnetic stimulation over the right M1 25 ms later (90 pairs at 0.05 Hz)...

The tongue plays important roles in a variety of critical human oral functions, including speech production, swallowing, mastication and respiration. These sophisticated tongue movements are in part finely regulated by cortical entrainment. Many studies have examined sensorimotor processing in the limbs using magnetoencephalography (MEG), which has high spatiotemporal resolution. Such studies h...

Although many people naively assume that the bite of carbonation is due to tactile stimulation of the oral cavity by bubbles, it has become increasingly clear that carbonation bite comes mainly from formation of carbonic acid in the oral mucosa. In Experiment 1, we asked whether bubbles were in fact required to perceive carbonation bite. Subjects rated oral pungency from several concentrations ...

A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea. advancement devices in 630 men and women with obstructive sleep apnea and snoring: tolerability and predictors of treatment success. Assessment of upper airway dynamics in awake sleep apnea patients wi...

promontory stimulation testing is both a valuable diagnosic tool and a crucial step in candidate selection for cochlear implantation. in this study we have compared the promontory stimulation test results between different subsets of patients with hearing loss in order to clarify the aspects of promontory stimulation which correlate best with the patients'characierisiics. patients with severe t...

postdate pregnancy is estimated to occur in 3% to 12% of all gestations. morbidity and mortality rates associated with this common obstetric problem are higher than those with term gestation. the incidence of fetal distress, birth injury, meconium aspiration, congenital malformations, macrosomia, and oligohydramnios is also greater in postdate pregnancies. we prospectively evaluated breast self...

Although taste can influence meal size and body weight, the neural substrate for these effects remains obscure. Dopamine, particularly in the nucleus accumbens, has been implicated in both natural and nonnatural rewards. To isolate the orosensory effects of taste from possible postingestive consequences, we investigated the quantitative relationship between sham feeding of sucrose and extracell...

The oral cavity is a complex microenvironment consisting of multiple bacterial and fungal species, their associated biofilms, and a cytokine milieu influenced by constant inflammatory stimulation. Multiple infectious consequences of poor oral health have been extensively described and primarily affect older adults. Probably the most common sequelae of poor oral health in aged persons is a risk ...

The aim of the study was to provoke cephalic and metabolic responses by oral fat stimulation with different high-fat meals in the postprandial state. A randomized parallel design was executed with three groups of subjects (twenty-six women and ten men; twelve subjects per group). Oral fat stimulation was achieved by the modified sham feeding (MSF) technique. Five hours after a high-fat breakfas...