Abstract Background Micro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used diagnostic and prognostic biomarkers could be considered therapeutic targets treating the same. Main body Studies proven that miRNAs play essential role molecular pathophysiology, including oral squamous cell carcinoma. Distinct expression profiles of different demonstrated Am...

S phase kinase-interacting protein 2 (Skp2), an F box protein, is required for the ubiquitination and consequent degradation of p27. It is well known that reduced expression of p27 is frequently observed in various cancers including oral squamous cell carcinoma and is due to an enhancement of its protein degradation. Our previous study showed that overexpression of Skp2 was frequently found in ...

Cancer-associated fibroblasts are amongst the key tumor microenvironment components that determine invasion, progression, and resistance to cancer therapeutics. Histologically normal mucosa adjacent oral squamous cell carcinoma has been shown harbor cancer-associated which aid in loco-regional recurrence of lesion. Read more at JCTRes.com

Introduction: A strong relationship exists between cigarette smoking and the development of oral squamous cell carcinoma. Smoking can significantly increase cellular proliferation. Nevertheless, there is little reference in literature to the cytological assessment of oral mucosa in this respect. Methods: Changes in nuclear and neucleolar cytomorphometric parameters such as diameter, surface, nu...

Fibroblast growth factor receptor 3 (FGFR3) is a member of the fibroblast growth factor receptor tyrosine kinase family. It has been identified as a promising therapeutic target in multiple types of cancer. We have investigated FGFR3 protein expression and FGFR3 gene copy-numbers in a single well-documented cohort of oral and oropharyngeal squamous cell carcinoma. Tissue microarray sets contain...

Heat-shock protein 90 (HSP90) is a major cellular chaperone protein. HSP90 supports the correct conformation, stabilization, activation, and localization of 'client' oncoproteins, many of which are involved in tumor progression. Therefore, the use of HSP90 inhibitors has become a new strategy in antitumor therapy. However, the effects of an HSP90 inhibitor on oral squamous cell carcinoma are st...

Within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. This has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (CSCs), has the capacity to self-renew and form new tumors . It has been proposed that the development of tumors is based exclusiv...