Wei Liu,* Yong Zhang and Bing Zhao School of Pharmacy, Xinxiang Medical University, Eastern JinSui avenue, Xinxiang 453003, P. R. China Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, P. R. China New Drug Research and Development Center, School of Pharmaceutical Science, Zhengzhou University, No. 100, KeXue avenue, Zhengzhou 450001, P. R. ...

The inadvertent intravenous administration of oral suspension which is rarely reported has contributed to potential patient harm. We received an incident report in a had liquid formulation intravenously. This been happening when prepared or dispensed parenteral syringe. Due the break-in mental concentration, medicine administered Some health professionals did not accept fact that Luer connectio...

the aim of this study was to investigate the effect of inflammatory pulpal pain on spatial learning and memory in male wistar rats. fifty-six adult rats were divided into eight groups as follows (n=7 per group): control, sham-operated group that received normal saline, sham vehicle group that received vehicle of capsaicin, three capsaicin treated groups that received intradental injection of 10...

several studies point to an important function of cyclooxygenase (cox) and prostaglandin signaling in models of synaptic plasticity which is associated with n-methyl-d-aspartate receptors (nmdars). cyclooxygenase gene is suggested to be an immediate early gene that is tightly regulated in neurons by nmda dependent synaptic activity. nonsteroid antiinflammatory drugs (nsaids) exert their antiinf...

A novel application of whole cells of Nocardia corallina B-276 for the deracemisation of ibuprofen is reported. This microorganism successfully hydrolysed ibuprofen nitrile to ibuprofen amide, and ibuprofen amide to ibuprofen, using a suspension of cells in a potassium phosphate buffer solution (0.1 M, pH = 7.0). These results can be explained by the presence of NHase and amidase enzymes, but t...

OBJECTIVE To evaluate the efficacy of oral anti-inflammatory or antibiotic treatment compared with placebo in the resolution of cough in patients with uncomplicated acute bronchitis and discoloured sputum. DESIGN Multicentre, parallel, single blinded placebo controlled, randomised clinical trial. SETTING Nine primary care centres in Spain. PARTICIPANTS Adults aged 18 to 70 presenting symp...

OBJECTIVES To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain. METHODS A randomised, double-blind, four-arm, parallel-group, active controlled trial investigating short-term (day 10) and long-term (week 13) benefits and side-effects of four regimens, each taken three times ...

Specific interventions included in the review Studies that evaluated NSAID therapy after surgery were included. The specific NSAIDs included were intravenous (i.v.) or intramuscular ketorolac (30 mg and 1 mg/kg), oral ibuprofen (5 mg/kg every 6 hours), or i.v. ketoprofen (3.5 mg/kg). The control groups received saline (3 studies), paracetamol plus codeine (2 studies), or either morphine or mepe...

Several studies point to an important function of cyclooxygenase (COX) and prostaglandin signaling in models of synaptic plasticity which is associated with N-methyl-D-aspartate receptors (NMDARs). Cyclooxygenase gene is suggested to be an immediate early gene that is tightly regulated in neurons by NMDA dependent synaptic activity. Nonsteroid Antiinflammatory Drugs (NSAIDs) exert their antiinf...

We defined response in acute pain trials according to percentage of maximum possible efficacy. Minimum efficacy criteria (MEC) of 0%, or at least 15%, 30%, 50%, and 70% pain relief were used to examine stability over time using total pain relief and summed pain intensity difference (SPID), sex differences, and sensitivity. We used individual patient data from placebo-controlled third molar extr...