The acute metabolic complications of diabetes consist of diabetic ketoacidosis (DKA), hyperosmolar non-ketotic coma (HNC), lactic acidosis (LA), and hypoglycemia. DKA and HNC are related to insulin deficiency. Hypoglycemia results from the treatment of diabetes, either with oral agents or insulin. Although hypoglycemia may occur in conjunction with oral hypoglycemic therapy, it is more common i...

The purpose of study was to compare the glycemic parameters- Fasting Blood Sugar (FBS), Postprandial blood sugar(PPBS), and HbA1C in subjects with Type 2 Diabetes Mellitus taking DPP4 Inhibitors versus other OHA either used aloneor combination oral hypoglycemic agents (OHA).Methods: attending outdoor indoor clinicsof Department Medicine suffering from type diabetes mellitus satisfying inclusion...

Numerous oral antidiabetic drugs with different mechanisms of action have been developed to lower glucose and delay the occurrence of serious complications in patients with type 2diabetes [1]. For glycemic control in diabetic patients, monotherapy with an oral antidiabetic agent is not adequate to achieve satisfactory blood glucose control [2]. Thus, combination regimens which include drugs wit...

AIMS/INTRODUCTION To compare the treatment satisfaction of four classes of oral hypoglycemic agents (OHAs): dipeptidyl peptidase-4 (DPP-4) inhibitors, α-glucosidase inhibitors (αGI), biguanides (BG) and sulfonylureas (SU), which are common initial treatments for type 2 diabetes mellitus patients in Japan, and to identify the best oral hypoglycemic agent in terms of treatment satisfaction. MAT...

Different doses of ethanolic extract of Stephania glabra tuber were evaluated for antihyperglycemic activity in alloxan induced diabetic mice. The oral administration of 100, 200 and 500 mg/kg body weight showed significant hypoglycemic activity. Glibenclamide (oral hypoglycemic agent, 25 mg/kg, p.o.) has been used as standard.

The global high prevalence of diabetes mellitus has resulted into the development several oral hypoglycemic agents. However, these drugs have limited efficacy and harmful side effects, which call for search alternatives from natural sources. inhibition dipeptidyl peptidase-4 (DPP-4) activity increases level glucagon-like peptide-1 glucose-dependent insulinotropic polypeptide, in turn reduces hy...