Preliminary observations on the effect of D(-)penicillamine on chronic antigen-induced experimental arthritis in rabbits are reported. Daily oral administration of penicillamine, at a dose equivalent to that usually administered to rheumatoid arthritis patients, diminished the arthritis in 2 out of 3 animals as assessed by both measurement of joint circumference and histological examination.

In order to compare the relative bioavailability of orally administered methotrexate (MTX) with i.m. administration in patients with rheumatoid arthritis, we compared the pharmacokinetics of MTX at both the usual starting dose of 7.5 mg and at higher established maintenance dosages in 21 patients. Pharmacokinetic measures were repeated approximately 6 and 18 months after baseline while patients...

Plasma concentrations and pharmacokinetics of enrofloxacin were determined in 12 loggerhead sea turtles (Caretta caretta) after oral administration. Six turtles in group 1 and group 2 received enrofloxacin at 10 mg/kg and 20 mg/kg of body weight, respectively. Blood was collected from the cervical sinus before administration and at timed intervals up to 168 hr following administration. Plasma c...

Serum theophylline levels were measured throughout the day in 65 asthmatic children receiving one of two slow-release theophylline compounds. There was a wide interindividual variation in levels obtained with similar doses of pure theophylline, and also a wide intraindividaual variation in levels throughout the day, suggesting that the rates of release and/or absorption of theophylline from the...

A 28-year-old male developed total external ophthalmoplegia following oral administration of phenytoin. The case is reported and its significance is discussed.

BACKGROUND Hyaluronan (HYA) is a high molecular weight glucosaminoglycan with a great perspective for medical applications. Because HYA is widespread in the body, it is difficult to determine the fate of exogenously administered HYA. METHODS In this study, HYAof different molecular weights (0.1-1 MDa) was labelled with (99m)Tc, and the distribution profiles were determined after administratin...

Most sylvatic species of Trichinella are known to have poor infectivity to rats, but in the present study oral administration of bile from other hosts appeared to modify this infectivity. A total of 75 rats were inoculated in groups of 25 with 3 species of Trichinella (T. spiralis, T. nativa, and T. nelsoni) and each group of rats was given per os daily doses of bile from pig, sheep, chicken an...

the effects of various routes of probiotic administration on performance, small intestine morphology and serum cholesterol of broiler chickens, were studied. we assigned 225 day old chicks (ross 308) to five experimental groups including control and four hatchery administration methods comprised of in ovo injection, oral gavage, spray application and cloacal inoculation. all of these were chall...

Rapid cyclic fluctuations of blood pressure in patients with a pheochromocytoma have rarely been reported. The suitable conditions to induce this phenomenon are not adequately known. We report here a patient with an adrenal pheochromocytoma who showed this phenomenon after oral administration of labetalol.