Since their discovery, carbon nanotubes have attracted the attention of many a scientist around the world. This extraordinary interest stems from their outstanding structural, mechanical, and electronic properties. In fact, apart from being the best and most easily available one-dimensional (1D) model system, carbon nanotubes show strong application potential in electronics, scanning probe micr...

BACKGROUND The use of SharePoint® collaboration software for content management has become a critical part of today's drug discovery process. SharePoint 2010 software has laid a foundation which enables researchers to collaborate and search on various contents. The amount of data generated during a transition of a single compound from preclinical discovery to commercialization can easily range ...

A bipolarly flagellated magnetotactic spirillum containing intracellular chains of single domain-sized magnetite crystals was isolated by applying a magnetic field to sediments from a freshwater swamp. The organism was cultured in a chemically defined medium containing ferric quinate and succinate as sources of iron and carbon, respectively. Nonmagnetic variants of this isolate were maintained ...

Rum is a sugar cane spirit obtained by the distillation of molasses through yeast fermentation and subsequent aging in wooden barrels, where the spirit acquires its special flavor and aroma. Packed bed schemes were applied to the accelerated aging of rum samples. These involved maturation in contact with natural, toasted or chemically treated oak wood chips for 90 d and four secondary treatment...

Nucleolytic enzymes are associated with various diseases, and several methods have been developed for their detection. DNase expression is modulated in such diseases as acute myocardial infarction, transient myocardial ischemia, oral cancer, stomach cancer, and malignant lymphoma, and DNase I is used in cystic fibroma therapy. RNase is used to treat mesothelial cancer because of its antiprolife...

Chemically dependent women must cope with their addictions while concomitantly combating stigmatism and blame as a consequence of their chemical dependency and being prone to certain health problems resulting from their addictions. The purpose of this article is to identify several key characteristics of women who abuse drugs: a) ethnicity, b) gender differences, c) patterns of female chemical ...

Sepsis was induced by cecal ligation.Chemically modified tetracyclines CMTs are derivatives of tetracycline group of drugs which lack antimicrobial action but have potent host modulating affects.Chemically Modified Tetracyclines: An Emerging Host Modulatory Therapy. 1Sonakshi Gupta and 2 Vidya Dodwad. 1Postgraduate student III Yr, Department.of chemically modified tetracyclines CMTs on the prod...

Nucleic acid aptamers are single-stranded DNA or RNA oligonucleotide sequences that bind to a specific target molecule with high affinity and specificity through their ability to adopt 3-dimensional structure in solution. Aptamers have huge potential as targeted therapeutics, diagnostics, delivery agents and as biosensors. However, aptamers composed of natural nucleotide monomers are quickly de...

Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues. Partially modified siRNAs (up to 70% of the nucleotides) provide significant stabilization in vitro and are commercially available; thus are commonly used to evaluate efficacy of bio-conjugates for in vivo delivery. In con...

Neural mechanisms underlying the onset and maintenance of epileptic seizures involve alterations in inhibitory and/or excitatory neurotransmitter pathways. Thus, the prospecting of novel molecules from natural products that target both inhibition and excitation systems has deserved interest in the rational design of new anticonvulsants. We isolated the alkaloids (+)-erythravine and (+)-11-α-hyd...