PURPOSE Different PDR treatment schemas are used in clinical practice, however optimal length of interval between pulses still remains unclear. The aim of this work was to compare value of BED doses measured in surrounded healthy tissues according to different intervals between pulses in PDRBT. Influence of doses optimization on BED values was analyzed. MATERIAL AND METHODS Fifty-one patients...

The objective of the current study was to investigate whether minocycline improves the effect of an existing multiple sclerosis (MS) medication, interferon-beta, on experimental autoimmune encephalomyelitis (EAE) in mice. When used at sub-optimal doses, neither medication affected EAE but their combination at these doses led to the significant alleviation of EAE disease severity scores and hist...

To determine the optimal time of folinic acid rescue after methotrexate (MTX) treatment in patients with ALL, we selected and evaluated relevant studies that included doses, rescue delay, and side effects. Rescue at 42-48 hours resulted in considerable toxicity, except when low doses of MTX were used (1 g/m(2)) or serum MTX levels remained consistently low at 24, 30, and 36 hours. Rescue starte...

This paper proposes a novel bayesian phase I/II design featuring using a hybrid mTPI method in phase I for targeting the MTD level and a randomization allocation schema for adaptively assigning patients to desirable doses in phase II. The mechanism of simultaneously escalating dose in phase I and expanding promising doses to phase II is inherited from a design proposed in literature. Extensive ...

N ADEQUATE method of control for the anticoagulant effect of dicumarol is an essential condition for the evaluation of effectiveness and danger of this therapy. Such a method should control the action of dicumarol only; it should be independent of accidental variations in clotting factors due to other causes . As long as these requirements are not fulfilled, the optimal dosage of dicumarol cann...

We measured anti-SARS-CoV-2 antibody responses before and after CoronaVac (inactivated) vaccination in a case–control study performed CoronaVac-immunized individuals participating longitudinal prospective of adults Manaus (DETECTCoV-19). Antibody were by standard serological immunoassays. Peak anti-S-RBD neutralizing RBD-ACE2 blocking two doses vaccine similar breakthrough cases (n = 9) matched...