We designed, fabricated and tested a novel imaging system that fuses diffuse optical tomography (DOT) and photoacoustic tomography (PAT) in a single platform. This platform takes advantages of both DOT and PAT, and can potentially provide dual-modality two dimensional functional and cellular images of the breast quantitatively. Here we describe this integrated platform along with initial tissue...

The Problem: Optical tomography (OT), as a potential diagnostic tool for detecting growths in translucent soft tissue, has been proposed and studied by several groups in recent years. Its principle is to use multiple movable light sources and detectors attached to the tissue surface to collect information on light attenuation, and to reconstruct the internal 3-D absorption and scattering distri...

We present a photoacoustic tomography-guided diffuse optical tomography approach using a hand-held probe for detection and characterization of deeply-seated targets embedded in a turbid medium. Diffuse optical tomography guided by coregistered ultrasound, MRI, and x ray has demonstrated a great clinical potential to overcome lesion location uncertainty and to improve light quantification accura...

In fluorescence diffuse optical tomography (fDOT), the accuracy of reconstructed fluorescence distributions highly depends on the knowledge of the tissue optical heterogeneities for correct modeling of light propagation. Common approaches are to assume homogeneous optical properties or, when structural information is available, assign optical properties to various segmented organs, which is lik...

t akotsubo cardiomyopathy (tcm), also known as stress-induced cardiomyopathy, is a clinical syndrome of transient left ventricular (lv) apical wall motion abnormality with relative preservation of the basal heart segments in the absence of any significant atherosclerosis. recurrence of this condition is rare. we report a postmenopausal woman, who experienced two episodes of tcm within 4 months ...

teratomas are rare germline tumors that originate from one or more embryonic germ cell layers. teratoma of the kidney is extremely rare, and less than 30 cases of primary intrarenal teratomas have been published to date. we report the main radiologic features of an unusual case of mature cystic teratoma arising from the left kidney in a two-year-old boy. a left-sided abdominal mass was detected...

conclusion considering the similar diagnostic efficacy of all voxel sizes, 300 µm voxel size can be used with adequate efficacy for detection of external root resorption defects with minimal patient radiation dose and the shortest scanning time. background selecting a voxel size that yields minimal radiation dose with no significant compromise of the diagnostic accuracy of cone beam computed to...

background coronary artery anomalies are not common, but could be very serious. objectives this study determines the frequency of coronary anomalies and normal variants by multi-detector-row computed tomography (mdct). patients and methods the results of cardiac mdct study in 2697 consecutive patients were analyzed retrospectively. acquisition was performed by a 64-detector row ct machine. imag...

objective: the diagnosis of vertical root fracture (vrf) in endodontically treated teeth is a clinical challenge due to lack of specific clinical and radiographic signs. although radiographic evaluation such as cbct is helpful, intracanal posts can produce artifacts and may impair the quality of cbct scans. this study aimed to compare the diagnostic accuracy of different resolutions of cbct in ...

Diffuse optical tomography (DOT) aims at recovering three-dimensional images of absorption and scattering parameters inside diffusive body based on small number of transmission measurements at the boundary of the body. This image reconstruction problem is known to be an ill-posed inverse problem, which requires use of prior information for successful reconstruction. We present a shape based met...