نتایج جستجو برای: optic nerve disease
تعداد نتایج: 1651312 فیلتر نتایج به سال:
BACKGROUND To report the ocular manifestations of neuro-Behcet's disease. CASES A 34-year-old woman had recurrent meningitis. She developed diplopia, headache, and ataxia, and was diagnosed as having neuro-Behcet's disease. OBSERVATIONS Imaging revealed two infarct foci in the transitional midbrain and pons. After treatment with prednisolone and colchicine, the diplopia resolved. Two years ...
AIMS To demonstrate the quantitative distribution of mitochondrial enzymes within the human optic nerve and retina in relation to the pathogenesis of ophthalmic disease. METHODS Enucleations were performed at the time of multiple organ donation and the optic nerve and peripapillary retina immediately excised en bloc and frozen. Reactivities of the mitochondrial enzymes cytochrome c oxidase an...
Hemangioblastomas are uncommon tumors that occur mostly in the cerebellum, medulla, and spinal cord. Supratentonal hemangioblastomas are rare [i ], and hemangioblastomas of the optic nerve have, to our knowledge, been reported in only eight previous cases, all of which were unilateral [2, 3]. We report a case of bilateral optic nerve hemangioblastomas, in which the resultant visual loss was the...
Optic neuropathy is common in mitochondrial disorders, but poorly characterized in Friedreich's ataxia (FRDA), a recessive condition caused by lack of the mitochondrial protein frataxin. We investigated 26 molecularly confirmed FRDA patients by studying both anterior and posterior sections of the visual pathway using a new, integrated approach. This included visual field testing and optical coh...
Glaucoma is a neurodegenerative disease of the eye and it is one of the leading causes of blindness. Glaucoma is characterized by progressive degeneration of retinal ganglion cells (RGCs) and their axons, namely, the optic nerve, usually associated with elevated intraocular pressure (IOP). Current glaucoma therapies target reduction of IOP, but since RGC death is the cause of irreversible visio...
BACKGROUND Fibrous dysplasia (FD) is a benign fibro-osseous lesion related to an abnormal bone development and replacement by fibrous tissue. FD has three clinical patterns namely monostotic, polyostotic, and the McCune-Albright syndrome (MAS). MAS is a rare genetic disorder (about 3% of all FD's) that comprises a triad of polyostotic FD, café-au-lait skin macules, and precocious puberty. MAS c...
BACKGROUND In clinical practice, the differentiation of glaucomatous from non-glaucomatous cupping can be difficult, even for experienced observers. The purpose of this study was to evaluate the role of optical coherence tomography (OCT) in differentiating glaucomatous from non-glaucomatous optic nerve cupping in a cross-sectional pilot study. METHODS Eleven consecutive patients presenting to...
A 52-year-old man presented with an anterior communicating artery aneurysm associated with splitting, penetration, and visual symptoms of the optic nerve and manifesting as sudden onset of severe headache. Angiography disclosed a 10-mm anterior communicating artery aneurysm projecting supero-posteriorly, and operative findings revealed unexpected splitting of the optic nerve. Moreover, the opti...
This study was to analyse the degeneration of the Retinal Nerve Fiber Layer (RNFL) and optic disc and the relationship between optic nerve damage and the severity of cognitive impairment in patients with Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). The RNFL thickness and optic disc variables were assessed by optical coherence tomography in patients with MCI and AD and control s...
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