Aberrant stimulation of the canonical Wnt pathway induces mammary tumorigenesis in mice. It has been well documented that two types of tumors, adenocarcinoma and adenocarcinoma with squamous metaplasia, develop in these mutants. However, the molecular mechanism underlying the induction of squamous transdifferentiation remains largely unknown. Here, we show that JNK/SAPK signaling plays an impor...

The circadian clock is known to regulate a wide range of physiological and cellular processes, yet remarkably little is known about its role during embryo development. Zebrafish offer a unique opportunity to explore this issue, not only because a great deal is known about key developmental events in this species, but also because the clock starts on the very first day of development. In this st...

Abstract An extensive MyCare Ohio process evaluation was conducted to understand factors affecting everyday implementation. This involved a review of membership enrollment data and qualitative interviews focus groups with state-level stakeholders (n=29), regional comprised Area Agency on Aging Plan personnel HCBS service providers (n=418), members (n=40); which were audio-recorded, transcribed,...

Since loops in data-flow visual languages (Hils 1992) may be difficult to understand (Green and Petre 1996), we decided to test the usability of the solutions we devised for VIPERS, a data-flow visual language developed at the University of Pavia (Ghittori, Mosconi and Porta 1998). To get useful indications, we opted for a comparative analysis, also referring to the well-known data-flow languag...