BACKGROUND Simvastatin increases the expression of bone morphogenetic protein 2 (BMP-2) in osteoblasts, therefore it is important to investigate the influence of statins on bone formation, fracture healing and implant integration. The aim of the present study was to investigate the effect of simvastatin, locally applied from intramedullary coated and bioactive implants, on bone integration usin...

Effects of green tea extract (GTE) on the activity of cytochrome P450 (CYP) enzymes and pharmacokinetics of simvastatin (SIM) were investigated in rats. Inhibitory effects of GTE on CYP3A activity were investigated in rat hepatic microsomes (RHM) using midazolam (MDZ) 1'-hydroxylation as a probe reaction. SD female rats received a single oral dose of GTE (400 mg/kg) or troleandomycin (TAO, a CY...

Mobile networks security is constantly evolving and adapting to meet the needs of users and network operators. It is a requirement that there be interoperation of legacy security frameworks into modern mobile networks. Mobile networks originally had no real security which proved to be a deployment that was attacked constantly and the providers were defrauded of millions of dollars. To address t...

The single-minded (sim) gene of Drosophila encodes a nuclear protein that plays a critical role in the development of the neurons, glia, and other nonneuronal cells that lie along the midline of the embryonic CNS. Using distinct cell fate markers, we observe that in sim mutant embryos the midline cells fail to differentiate properly into their mature CNS cell types and do not take their appropr...

OBJECTIVE Statins are widely used lipid-lowering drugs, which have pleiotropic effects, such as anti-inflammation, and vascular protection. In our study, we investigated the radioprotective potential of simvastatin (SIM) in a murine model of radiation-induced salivary gland dysfunction. DESIGN Ninety-six Institute of Cancer Research mice were randomly divided into four groups: solvent + sham ...

The single-minded (sim) gene encodes a transcriptional regulator that functions as a key determinant of central nervous system (CNS) midline development in Drosophila. We report here the identification of two murine homologs of sim, Sim1 and Sim2, whose products show a high degree of sequence conservation with Drosophila SIM in their amino-terminal halves, with each containing a basic helix-loo...

By combining SIM observations with ground-based photometry, one can completely solve microlensing events seen toward the Galactic bulge. One could measure the mass, distance, and transverse velocity of ∼ 100 lenses to ∼ 5% precision in only ∼ 500 hours of SIM time. Among the numerous applications are 1) measurement of the mass functions (MFs) of the bulge and disk 2) measurement of the relative...