open loop php

In our search for a more versatile protecting group that would exhibit fast release rates for peptides, we have designed and developed the p-hydroxyphenacyl (pHP) group as a new photoremovable protecting group. We report the application of this protecting group for the dipeptide Ala-Ala (1) and for the nonapeptide bradykinin (2), two representative peptides that demonstrate C-terminus “caging” ...

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Evaluation of a standardized short-time calcium suppression test in healthy subjects: interest for the diagnosis of primary hyperparathyroidism.

Journal: :European journal of endocrinology 2007

Isabelle Titon Anne Cailleux-Bounacer Jean Pierre Basuyau Hervé Lefebvre Adeline Savouré Jean Marc Kuhn

OBJECTIVE The diagnosis of primary hyperparathyroidism (PHP) can be difficult in patients with normal plasma calcium or parathyroid hormone (PTH) levels. We perfected a standardized short-time i.v. calcium loading test in healthy controls (HC) and compared the results with those of patients with PHP. METHODS Sixteen HC received 0.33 mmol/kg calcium gluconate intravenously for 3 h. Plasma calc...

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