Carbapenem-resistant Acinetobacter baumannii (CRAb) have emerged in recent decades as major causes of nosocomial infections. Resistance is mainly due to overexpression of intrinsic and/or acquired carbapenemases, especially oxacillinases (OXA). In Italy, although the sequence type (ST) 2 and the ST78 are the most frequently detected, we recently reported ST632, a single locus variant of ST2. Th...

Membrane proteins (MPs) are essential for numerous important biological processes. Recently, mass spectrometry (MS), coupled with an array of related techniques, has been used to probe the structural properties of MPs and their complexes. Typically, detergent micelles have been employed for delivering MPs into the gas-phase, but these complexes have intrinsic properties that can limit the utili...

Integral beta-barrel proteins (OMPs) are a major class of outer membrane proteins in Gram-negative bacteria. In Escherichia coli, these proteins are synthesized in the cytoplasm, translocated across the inner membrane via the Sec machinery, and assembled in the outer membrane through an unknown mechanism that requires the outer membrane YaeT complex and the periplasmic chaperones SurA, DegP, an...

Background Pricing and reimbursement authorities often lack sufficient information to decide about Orphan Medicinal Products (OMPs), because of pricing, high levels of uncertainty and small datasets, amongst others. EU Member States share similar challenges as they seek to include OMPs appropriately in their healthcare systems. The “Process on Corporate Responsibility in the field of Pharmaceut...

The agents of leptospirosis, a zoonosis with worldwide distribution, are pathogenic spirochetes belonging to the genus Leptospira. The leptospiral life cycle involves transmission via fresh water and colonization of the renal tubules of their reservoir hosts. Infection of accidental hosts, including humans, may result in life-threatening sequelae. Bacterial outer membrane proteins (OMPs), parti...

This study compared the proteomic profile of outer membrane proteins (OMPs) from one strain of atypical enteropathogenic Escherichia coli (aEPEC) and one of typical EPEC (tEPEC). The OMPs fractions were obtained using sarcosine extraction, and analyzed by one- and two-dimensional gel electrophoresis (1DE and 2DE, respectively). The 1DE OMPs analysis of typical and atypical EPEC evidenced simila...

Monitoring the removal of organic micropollutants (OMPs) in advanced wastewater treatment facilities requires expensive and time-consuming analytical methods that cannot be installed online. Spectroscopic techniques such as fluorescence excitation/emission spectroscopy were demonstrated to offer potential for monitoring OMPs conventional plants or ozonation pilots but their application activate...

Optical-model potentials (OMPs) continue to play a key role in nuclear reaction calculations. However, the uncertainty of phenomenological OMPs widespread use---inherent any parametric model trained on data---has not been fully characterized, and its impact downstream users remains unclear. Here we assign well-calibrated uncertainties for two representative global OMPs, those Koning-Delaroche C...

Conventional drinking water treatment is inefficient in removing a large fraction of known organic micropollutants (OMPs). Ozonation combination with granular activated carbon promising approach for addressing this issue.

We report the development of a temperature profile data set from Ozone Mapping and Profiler Suite Limb (OMPS-LP) instrument on Suomi NPP satellite. The covers roughly 10 year period 2012 to 2022, temperatures are provided in altitude range between 35 70 km. algorithm uses daytime Rayleigh scattered radiation near 350 nm estimate atmospheric density profiles, which vertically integrated using hy...