•CAR-IKZF3 degron expression and CART activity can be regulated in vitro•IMiD treatment controls CART-IKZF3 anti-tumor efficacy vivo•Such strategy aims to mitigate potential toxicities associated with therapy•The IKZF3/lenalidomide pair is portable other membrane proteins The recent development of successful CAR (chimeric antigen receptor) T cell therapies has been accompanied by a need better ...

abstract ovarian tissue freezing or cryopreservation might be the only acceptable method for preserving the young women fertility, before radiotherapy or chemotherapy. this technology might be used for patients with recurrent ovarian cysts or endometriosis, without ovarian stimulation. many efforts have made to improve cryopreservation conditions that should be seriously considered for cancer p...

s of the Talks In the order in which the talks were given. Walter Carnielli { Non-deterministic Semantics 5 Matthias Baaz { Analytic Calculi for Many-valued Logics 5 Hiroakira Ono { Many-valued Logics as Logics without the Contraction Rule 6 Reiner H ahnle { Proof Theory of Many-valued Logic and Hardware Design 7 Gonzalo Escalada-Imaz { Determining the Truth Degree in Real Time Settings 7 Pete...

This paper examines one of the less-discussed modes of anti-globalization, relocalization or local autonomy. It describes a range of autonomous movements, summarizes their political economic ideas, and discusses some common social critiques raised in regard to local autonomy. Apologists for the costly side effects of the globalization process argue that integration into the global economy bring...

24 The factors that influence the timing of puberty and the onset of adult fertility are poorly 25 understood. While focus on the juvenile period has provided insights into how growth-related 26 cues affect pubertal timing, growth velocity during infancy that is sustained into the juvenile 27 period may be important. On the other hand, social factors, specifically exposure to 28 psychosocial st...

An adverse uterine environment is thought to program blood pressure (BP) later in life, most likely due to fetal under-nutrition. This study examines the relationships between adult systolic blood pressure (SBP) and diastolic blood pressure (DBP), birth weight, and maternal nutritional status and dietary intake during pregnancy. This study draws on a large sample (n=1632) of Filipino young adul...

perspective, labels represent an extra `informational resource' which is present in deduction and can play a variety of roles. One obtains a scala of labeling regimes depending on the degree of autonomy between the formula component and the label component of the basic declarative units. At the conservative end of the spectrum, the label simply keeps a passive record of inferential steps. Curry...