Certain symmetric linear multistep methods have an excellent long-time behavior when applied to second order Hamiltonian systems with or without constraints. For high accuracy computations round-off can be the dominating source of errors. This article shows how symmetric multistep methods should be implemented, so that round-off errors are minimized and propagate like a random walk.

China has significant gaps and weaknesses in its regulatory oversight of the off-label use of drugs. As in the United States, the off-label prescribing of drugs is not prohibited in China if there is a sound scientific basis. Physicians are allowed to prescribe off-label drugs based on their medical judgment if they follow certain requirements. There is some constraint on the right to prescribe...

A new treatment for homotopy perturbation method is introduced. The new treatment is called He-Laplacemethodwhich is the coupling of the Laplace transform and the homotopy perturbation method using He’s polynomials. The nonlinear terms can be easily handled by the use of He’s polynomials. The method is implemented on linear and nonlinear partial differential equations. It is found that the prop...

This case highlights clinical dilemmas faced by physicians when treating patients with conditions for which there are limited or no FDA-approved treatment options. First, it raises questions about when it is appropriate to prescribe medications for "off-label" indications and what might be the ethical and legal implications of doing so. It also prompts us to consider why pharmaceutical companie...

Introduction Despite their limited licensed indications, anti-IL1 agents are often used in real-life practice for an increasing number of diseases. A national survey to record their off-label use in France was started in January 2011. The survey is coordinated by the French National Reference Centre for Auto-inflammatory Diseases, under the aegis of the “Club Rhumatisme et Inflammation” (CRI).

Over the last years managers have expanded their role in operations and nowadays they make decisions faster than in the past. Collaboration technology promises to support managers in doing so. Hence, the present situation is favorable for a redesign of management support systems (MSS) incorporating collaboration technology. To examine such technology, we consider “analyst”and “consumer”-type ma...

Point-of-care testing (POCT) is in the fact laboratory testing provided near the site of patient care or directly in this place. POCT includes in the present time bedside testing, near-patient testing, physicians ́ office testing, extra-laboratory testing, decentralized testing, off-site, ancillary, and alternative testing, and, of course, point-of-care testing. Laboratorian and clinical staff o...

The aim of the reported research was to examine the perceptions of road user safety amongst different road users and examine the link between attitudes, empathy and skill in motorcycle safety behaviour. Motorcyclists were perceived by the study participants, members of the public at four different locations at the UK (including motorcyclists and non-motorcyclists), as a group be at a high risk ...

Since the creation of the European Union Emissions Trading Scheme (EU ETS) in 2005, a burgeoning academic literature has emerged to identify the factors that shape the price of carbon, where one European Union Allowance is equal to one ton of CO2-equivalent emitted in the atmosphere. Thus, there is a need for an updated and thorough literature review on the state-of-the-art on topic that this p...

Deliberation, i.e., discussing and ranking different proposals and making decisions, is an important issue for many communities, be they political, be they boards of experts for a scientific issue. Online deliberation however has issues, such as unorganized content, off-topic or repetition postings, or aggressive and conflicting behavior of participants. To address these issues, based on a rela...