Background: Follicular occlusion tetrad (FOT) is a clinical syndrome consisting of suppurative hidradenitis, acne conglobata, dissecting cellulitis of the scalp, and pilonidal sinus. FOT is a rare case that is mostly found in severe conditions resulting in resistance to therapy. Diagnostic accuracy and therapy for all components of FOT is extremely important. Case: A 43-year old male presented ...

Perifolliculitis capitis abscedens et suffodiens or dissecting cellulitis of the scalp is a rare, chronic destructive folliculitis of the scalp, characterized by painful nodules, purulent drainage, sinus tracts, keloid formation and cicatricial alopecia. The cause of the disease is unknown, but it is similar in many features to hidradenitis suppurativa and acne conglobata. In our case report, t...

A 38-year-old Caucasian male presented to our department with 8 months of progressive painful subcutaneous nodules and abscesses in occipital scalp that caused numerous areas of alopecia (Figure 1). He had received treatment with isotretinoin due to acne conglobata two years back. Skinbiopsy specimen revealed a deep, chronic inflammatory infiltrate affecting the inferior portion of hair follicl...

Keratitis-Ichthyosis-Deafness syndrome is a rare congenital disorder of the ectoderm caused by mutations in the connexin-26 gene (GJB2) on chromosome 13q11-q12, giving rise to keratitis, erythrokeratoderma and neurosensory deafness. We report the case of a 31-year-old black male diagnosed as having KID syndrome. Sequencing analysis showed a heterozygous missense mutation D50N (148G > A) in the ...

The chemotactic activity of normal human polymorphonuclear leukocytes (PMNs) confronted with heat inactivated sera from patients with psoriasis as well as various chronic proliferative diseases was determined using modified Boyden chambers. By the addition of phorbol myristate acetate (PMA) at a concentration of 1 ng/ml the chemoattractant activities of the sera were greatly potentiated. Howeve...

CMAJ • APRIL 19, 2011 • 183(7) © 2011 Canadian Medical Association or its licensors E430 Acne vulgaris has a substantial impact on a patient’s quality of life, affecting both self-esteem and psychosocial development.1 Patients and physicians are faced with many over-the-counter and prescription acne treatments, and choosing the most effective therapy can be confusing. In this article, we outlin...

In an inherited genetic hypersensitivity, normai levels of androgens may cause cosmetic disturbances or even dermatologica! diseases: acne and alopecia. The cosmetic dermatologist is called for help. Androgenetic stimulation leads to increased levels of sebum, to an imbalance of lipids on the skin surface, to follicular hyperkeratosis and, finally, to the fonnation of comedones. In those patien...